Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from thalictrum przewalskii

AJ Al-Rehaily; MHM Sharaf; MA Zemaitis; Cy Gao; GE Martin; CE Hadden; TJ Thamann; Ft Lin; PL Schiff Jr

doi:10.1021/np9802217

Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from thalictrum przewalskii

J Nat Prod. 1999 Jan;62(1):146-8. doi: 10.1021/np9802217.

Authors

AJ Al-Rehaily¹, MHM Sharaf, MA Zemaitis, Cy Gao, GE Martin, CE Hadden, TJ Thamann, Ft Lin, PL Schiff Jr

Affiliation

¹ Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, Department of Spectral Analysis, Beijing Medical University, Beijing, 100083, China, Pharmaceutical Development, Pharmacia &

PMID: 9917304
DOI: 10.1021/np9802217

Abstract

A novel oxobenzylisoquinoline alkaloid, thalprzewalskiinone (1), was isolated from the roots of Thalictrum przewalskii, and its structure was established via spectroscopic analysis. Five other alkaloids were isolated: the protoberberines pseudocoptisine and berberine, the aporphines (+)-N-methylnantenine and (+)-magnoflorine, and the simple isoquinolone N-methyl-6,7-dimethoxyisoquinolone. Isovanillin was also isolated from this extract.