Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity

J Rheumatol. 1999 Jan;26(1):78-80.


Objective: In view of evidence that stromelysin-1 and collagenase-1 are involved in tissue injury in inflammatory joint diseases, we sought to determine whether matrix metalloproteinases (MMP) are implicated in the pathophysiology of systemic lupus erythematosus (SLE).

Methods: Seventy-three patients with SLE and 39 healthy subjects were evaluated. Serum levels of MMP and tissue inhibitor of metalloproteinases were measured.

Results: Serum stromelysin-1 levels were significantly increased in patients with SLE (416+/-252 ng/ml) compared to healthy subjects (125+/-93 ng/ml). No correlation between serial measurements of stromelysin-1 and disease activity in SLE patients was noted. Serum collagenase-1, gelatinase A, and TIMP-1 levels were not increased in SLE.

Conclusion: Serum concentrations of stromelysin-1 are increased in SLE, but the levels do not correlate with disease activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Disease Progression
  • Humans
  • Immunohistochemistry
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / enzymology
  • Lupus Erythematosus, Systemic / physiopathology
  • Matrix Metalloproteinase 3 / blood*
  • Metalloendopeptidases / blood
  • Prospective Studies
  • Tissue Inhibitor of Metalloproteinase-1 / blood


  • Tissue Inhibitor of Metalloproteinase-1
  • Metalloendopeptidases
  • Matrix Metalloproteinase 3