Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1alpha inhibit signaling by KSHV G protein-coupled receptor

Biochem Biophys Res Commun. 1998 Dec 30;253(3):725-7. doi: 10.1006/bbrc.1998.9557.


Kaposi's sarcoma-associated herpesvirus (KSHV) encodes two proteins that are similar to human CC chemokines and a G protein-coupled receptor (KSHV-GPCR) that is constitutively active. KSHV-GPCR binds a number of human CXC and CC chemokines. We showed that interferon gamma-inducible protein-10 (IP-10), a human CXC chemokine, inhibits KSHV-GPCR signaling (Geras-Raaka et al., J. Exp. Med. 188, 405-408, 1998). Here we show that viral monocyte inflammatory protein-II (vMIP-II), one of the KSHV-encoded CC chemokines, and stromal cell-derived factor 1alpha (SDF-1alpha), a human CXC chemokine that blocks infection by human immunodeficiency virus-type 1, inhibit KSHV-GPCR signaling also. If KSHV-GPCR signaling is involved in viral pathogenesis, then these chemokines may affect the course of Kaposi's sarcoma and primary effusion lymphoma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chemokine CXCL12
  • Chemokines / pharmacology
  • Chemokines, CC / pharmacology*
  • Chemokines, CXC / pharmacology*
  • Dose-Response Relationship, Drug
  • Herpesvirus 8, Human / metabolism*
  • Humans
  • Receptors, Chemokine / metabolism*
  • Signal Transduction / drug effects
  • Viral Proteins / metabolism*


  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines
  • Chemokines, CC
  • Chemokines, CXC
  • G protein-coupled receptor, Human herpesvirus 8
  • Receptors, Chemokine
  • Viral Proteins
  • vMIP-II