Conventional vs. newer antipsychotics in elderly patients

Am J Geriatr Psychiatry. Winter 1999;7(1):70-6.

Abstract

Elderly patients with schizophrenia and dementia patients with agitation are frequently candidates for antipsychotic treatment. Conventional neuroleptics have relatively little effect on negative symptoms and may cause considerable side effects, especially in elderly patients. The authors have found a 29% cumulative annual incidence of tardive dyskinesia (TD) in middle-aged and elderly outpatients treated with relatively low doses of conventional neuroleptics Newer antipsychotics are less likely to cause extrapyramidal symptoms and may be associated with a lower risk of TD. They are generally effective for both positive and negative symptoms and may also improve some aspects of cognition, but these drugs have their own side effects. Dosing requirements for elderly patients tend to be much lower than those for younger adults.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adult
  • Aged
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Benzodiazepines
  • Clozapine / adverse effects
  • Clozapine / therapeutic use
  • Dementia / complications*
  • Dibenzothiazepines / adverse effects
  • Dibenzothiazepines / therapeutic use
  • Dose-Response Relationship, Drug
  • Dyskinesia, Drug-Induced / etiology
  • Dyskinesia, Drug-Induced / prevention & control*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Olanzapine
  • Pirenzepine / adverse effects
  • Pirenzepine / analogs & derivatives
  • Pirenzepine / therapeutic use
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / etiology
  • Quetiapine Fumarate
  • Risperidone / adverse effects
  • Risperidone / therapeutic use
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents
  • Dibenzothiazepines
  • Benzodiazepines
  • Quetiapine Fumarate
  • Pirenzepine
  • Clozapine
  • Risperidone
  • Olanzapine