Expression of platelet-derived endothelial cell growth factor (PD-ECGF) related to angiogenesis in ovarian endometriosis

J Clin Endocrinol Metab. 1999 Jan;84(1):359-62. doi: 10.1210/jcem.84.1.5372.


Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

MeSH terms

  • Adult
  • Endometriosis / etiology*
  • Endometriosis / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Neovascularization, Pathologic / complications*
  • Ovarian Diseases / etiology*
  • RNA, Messenger / analysis
  • Thymidine Phosphorylase / analysis*
  • Thymidine Phosphorylase / genetics


  • RNA, Messenger
  • Thymidine Phosphorylase