The effects of two UVB radiation-absorbing sunscreens on UV radiation-induced carcinogenesis, suppression of the contact hypersensitivity response and histological changes in the hairless mouse

Mutat Res. 1998 Nov 9;422(1):161-4. doi: 10.1016/s0027-5107(98)00188-2.

Abstract

The research summarised in this report suggests that the two UVB-absorbers, o-PABA and 2-EHMC, have different modes of protection against UV radiation-induced immunosuppression, carcinogenesis and histological alterations, that appear to be independent of their SPF values, within experimental limits. The UVB-absorber o-PABA appears offer a valuable level of protection against photocarcinogenesis.

MeSH terms

  • 4-Aminobenzoic Acid / pharmacokinetics
  • 4-Aminobenzoic Acid / pharmacology*
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Cinnamates / pharmacokinetics
  • Cinnamates / pharmacology*
  • Dermatitis, Contact / prevention & control*
  • Dinitrofluorobenzene
  • Immune Tolerance / drug effects
  • Immune Tolerance / radiation effects
  • Mice
  • Mice, Hairless
  • Skin / drug effects
  • Skin / immunology
  • Skin / pathology
  • Skin / radiation effects*
  • Sunscreening Agents / pharmacokinetics
  • Sunscreening Agents / pharmacology*
  • Ultraviolet Rays*

Substances

  • Anticarcinogenic Agents
  • Cinnamates
  • Sunscreening Agents
  • octylmethoxycinnamate
  • Dinitrofluorobenzene
  • 4-Aminobenzoic Acid