A comparison of rectal and subcutaneous body temperature measurement in the common marmoset

J Pharmacol Toxicol Methods. 1998 Jul;40(1):21-6. doi: 10.1016/s1056-8719(98)00030-6.

Abstract

Two methods of measuring body temperature were compared in common marmosets. Subcutaneous temperatures were measured remotely via previously implanted subcutaneous microchips (Plexx BV, IPTT-100) prior to measurement of rectal temperature using a conventional rectal probe. Marmosets were treated with saline or the brain penetrant, 5-HT1A/B/D receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (0.3-3 mg/kg SC), which has previously been shown to induce hypothermia in guinea pigs. Body temperature was sampled immediately before drug administration and at 30-min intervals thereafter for a period of 2.5 h. SKF-99101H dose-dependently induced hypothermia in the common marmoset and there was close agreement between rectal and subcutaneous body temperatures, with an average difference in absolute body temperature of 0.26+/-0.02 degrees C. The data show that subcutaneously implanted microchips provide a simple, reliable measure of body temperature in common marmosets which is sensitive to pharmacological intervention, minimizes handling induced stress, and is minimally invasive.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Body Temperature / drug effects
  • Body Temperature / physiology*
  • Callithrix
  • Female
  • Indoles / pharmacology
  • Male
  • Rectum / drug effects
  • Rectum / physiology*
  • Serotonin Receptor Agonists / pharmacology
  • Skin Temperature / drug effects
  • Skin Temperature / physiology*
  • Time Factors

Substances

  • Indoles
  • Serotonin Receptor Agonists
  • SKF 99101H