TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal

Biochem Biophys Res Commun. 1999 Jan 8;254(1):203-10. doi: 10.1006/bbrc.1998.9893.


Using the cDNA-representative differences analysis (cDNA-RDA) approach, we identified a novel gene, TFAR19 (TF-1 cell apoptosis related gene-19), from TF-1 cells undergoing apoptosis. The human TFAR19 encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. TFAR19 exhibits a ubiquitous expression pattern and its expression is upregulated in the tumor cells undergoing apoptosis. Overexpression of TFAR19 in tumor cells enhances apoptosis triggered by growth factor or serum deprivation. We propose that TFAR19 may play a general role in the apoptotic process.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / genetics*
  • Apoptosis Regulatory Proteins
  • Base Sequence
  • Genes, Tumor Suppressor*
  • Growth Substances / deficiency
  • Humans
  • Leukemia / genetics*
  • Leukemia / metabolism
  • Leukemia / pathology
  • Mice
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Sequence Alignment
  • Tumor Cells, Cultured
  • Up-Regulation


  • Apoptosis Regulatory Proteins
  • Growth Substances
  • Neoplasm Proteins
  • PDCD5 protein, human
  • Pdcd5 protein, mouse

Associated data

  • GENBANK/AF014955