Resveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model

Biochem Biophys Res Commun. 1999 Jan 27;254(3):739-43. doi: 10.1006/bbrc.1998.9916.

Abstract

Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G2/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Cycle / drug effects
  • Cell Division / drug effects*
  • Flow Cytometry
  • Liver Neoplasms, Experimental / pathology*
  • Rats
  • Resveratrol
  • Stilbenes / pharmacology*
  • Wine / analysis*

Substances

  • Antineoplastic Agents, Phytogenic
  • Stilbenes
  • Resveratrol