A controlled trial of exercise rehabilitation after heart transplantation

N Engl J Med. 1999 Jan 28;340(4):272-7. doi: 10.1056/NEJM199901283400404.


Background: In patients who have received a cardiac transplant, the denervated donor heart responds abnormally to exercise and exercise tolerance is reduced. The role of physical exercise in the treatment of patients who have undergone cardiac transplantation has not been determined. We assessed the effects of training on the capacity for exercise early after cardiac transplantation.

Methods: Twenty-seven patients who were discharged within two weeks after receiving a heart transplant were randomly assigned to participate in a six-month structured cardiac-rehabilitation program (exercise group, 14 patients) or to undergo unstructured therapy at home (control group, 13 patients). Each patient in the exercise group underwent an individualized program of muscular-strength and aerobic training under the guidance of a physical therapist, whereas control patients received no formal exercise training. Cardiopulmonary stress testing was performed at base line (within one month after heart transplantation) and six months later.

Results: As compared with the control group, the exercise group had significantly greater increases in peak oxygen consumption (mean increase, 4.4 ml per kilogram of body weight per minute [49 percent] vs. 1.9 ml per kilogram per minute [18 percent]; P=0.01) and workload (mean increase, 35 W [59 percent] vs. 12 W [18 percent]; P=0.01) and a greater reduction in the ventilatory equivalent for carbon dioxide (mean decrease, 13 [20 percent] vs. 6 [11 percent]; P=0.02). The mean dose of prednisone, the number of patients taking antihypertensive medications, the average number of episodes of rejection and of infection during the study period, and weight gain did not differ significantly between the groups.

Conclusions: When initiated early after cardiac transplantation, exercise training increases the capacity for physical work.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Blood Pressure
  • Exercise Test
  • Exercise Therapy*
  • Exercise Tolerance
  • Female
  • Heart Transplantation / physiology
  • Heart Transplantation / rehabilitation*
  • Humans
  • Male
  • Middle Aged
  • Oxygen Consumption
  • Prospective Studies