Sweet's syndrome during treatment with all-trans retinoic acid in a patient with acute promyelocytic leukemia

Leuk Lymphoma. 1998 Nov;31(5-6):613-5. doi: 10.3109/10428199809057622.

Abstract

A 46 year old male with acute promyelocytic leukemia treated with all-trans retinoic acid (ATRA), developed fever, bilateral erythematous nodules in his axillary area, lower abdomen and inguinal region. Histopathologic examination of the skin biopsy revealed dense neutrophil infiltration in the dermis without vasculitis. The diagnosis of Sweet's syndrome was made. High dose methylprednisolone was administered and the lesions started to improve within 24 hours.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antineoplastic / therapeutic use
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Cytokines / metabolism
  • Glucocorticoids / therapeutic use
  • Humans
  • Idarubicin / therapeutic use
  • Leukemia, Promyelocytic, Acute / complications*
  • Leukemia, Promyelocytic, Acute / drug therapy
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Remission Induction
  • Sweet Syndrome / chemically induced
  • Sweet Syndrome / diagnosis
  • Sweet Syndrome / drug therapy
  • Sweet Syndrome / etiology*
  • Sweet Syndrome / pathology
  • Tretinoin / adverse effects*
  • Tretinoin / therapeutic use

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Cytokines
  • Glucocorticoids
  • Tretinoin
  • Methylprednisolone
  • Idarubicin