Knockout mouse model and gametogenic failure

Mol Cell Endocrinol. 1998 Oct 25;145(1-2):161-6. doi: 10.1016/s0303-7207(98)00183-x.


To evaluate the function of a defined gene in gametogenesis, exciting opportunities are offered by the introduction of techniques to generate knockout mice. In this short article, we briefly describe a few gene knockout mouse models, which show a phenotype that involves impairment of gametogenesis and/or fertility. The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Female
  • Gene Expression
  • Infertility, Male / enzymology
  • Infertility, Male / genetics*
  • Ligases / genetics
  • Ligases / metabolism
  • Male
  • Mice
  • Mice, Knockout
  • Oogenesis / genetics*
  • Oogenesis / physiology
  • Phenotype
  • Spermatogenesis / genetics*
  • Spermatogenesis / physiology
  • Ubiquitin-Conjugating Enzymes
  • Ubiquitins / metabolism


  • Ubiquitins
  • Ubiquitin-Conjugating Enzymes
  • Ligases