Protection against chemotherapy toxicity by IV hyperalimentation

Cancer Treat Rep. 1978 Aug;62(8):1139-43.

Abstract

A prospective randomized trial was conducted comparing the addition of iv hyperalimentation (IVH) to Corynebacterium parvum, isophosphamide, and adriamycin (CIA) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. Thirteen patients were entered in each treatment arm of the study and IVH was administered before and after the first course of CIA for a total of 31 days. The major dose-limiting toxic effect of CIA was leukopenia. Less myelosuppression was observed for the patients receiving IVH. The difference in the lowest recorded leukocyte and neutrophil counts between the two groups was significant (P = 0.03 and 0.01, respectively). Also, a significant decrease (P = 0.06) in nausea and vomiting associated with chemotherapy administration was found for the IVH gorup. The differences in toxic effects between each group were not maintained over subsequent courses of therapy when both groups received CIA alone. The prevention of the toxic effects of chemotherapy by IVH suggests a means of giving higher chemotherapy doses with the intent of increasing tumor response and patient survival.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Vaccines / therapeutic use
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / therapy*
  • Doxorubicin / adverse effects
  • Doxorubicin / therapeutic use
  • Evaluation Studies as Topic
  • Humans
  • Ifosfamide / adverse effects
  • Ifosfamide / therapeutic use
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / therapy*
  • Parenteral Nutrition* / adverse effects
  • Parenteral Nutrition, Total* / adverse effects
  • Propionibacterium acnes / immunology

Substances

  • Bacterial Vaccines
  • Doxorubicin
  • Ifosfamide