The chromosomal 2'-N-acetyltransferase of Providencia stuartii: physiological functions and genetic regulation

Front Biosci. 1999 Feb 1;4:D132-40. doi: 10.2741/macinga.


Intrinsic chromosomal acetyltransferases involved in aminoglycoside resistance have been identified in a number of bacteria. In Providencia stuartii, a chromosomal acetyltransferase (AAC(2')-Ia) has been characterized in detail. In addition to the ability to acetylate aminoglycosides, the AAC(2')-Ia enzyme has at least one physiological function, which is the acetylation of peptidoglycan. This modification is likely to influence the autolytic system in P. stuartii. The regulation of aac(2')-Ia expression is extremely complex involving at least seven regulatory genes acting in at least two pathways. This complexity in regulation indicates that aac(2')-Ia expression must be tightly controlled in response to different environmental conditions. This presumably reflects the importance of maintaining correct levels of peptidoglycan acetylation. In this review, a summary of data will be presented involving both the physiological and genetic aspects of aac(2')-Ia in P. stuartii.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetyltransferases / genetics*
  • Acetyltransferases / physiology*
  • Aminoglycosides
  • Drug Resistance, Microbial / genetics
  • Genes, Regulator / physiology
  • Providencia / enzymology*


  • Aminoglycosides
  • Acetyltransferases
  • aminoglycoside 2'-N-acetyltransferase