Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

Ann Hum Genet. 1998 Jul;62(Pt 4):291-8. doi: 10.1046/j.1469-1809.1998.6240291.x.


A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Australia
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16*
  • Crohn Disease / genetics*
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease*
  • Genotype
  • Haplotypes
  • Humans
  • Inflammatory Bowel Diseases / genetics*
  • Lod Score
  • Male
  • Pedigree