Hemoptysis due to MDI therapy in a patient with permanent tracheostomy: treatment with mask AeroChamber

Chest. 1999 Jan;115(1):279-82. doi: 10.1378/chest.115.1.279.


Persistent minor hemoptysis resulted from extensive granulation tissue on the main carina and adjacent bronchi due to frequent spraying of metered-dose inhaler (MDI)-generated aerosol medications directly into a permanent tracheostomy. Salbutamol, containing oleic acid, was considered the most likely cause. After an AeroChamber equipped with an infant mask was interposed between the MDI and the tracheal stoma, hemoptysis and the pathologic changes gradually resolved.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Albuterol / administration & dosage
  • Albuterol / adverse effects*
  • Diagnosis, Differential
  • Granulation Tissue / drug effects
  • Granulation Tissue / pathology
  • Hemoptysis / chemically induced*
  • Hemoptysis / pathology
  • Humans
  • Laryngectomy
  • Lung Diseases, Obstructive / drug therapy*
  • Male
  • Middle Aged
  • Nebulizers and Vaporizers*
  • Oleic Acid / administration & dosage
  • Oleic Acid / adverse effects*
  • Postoperative Complications / drug therapy*
  • Postoperative Complications / pathology
  • Tracheostomy*


  • Oleic Acid
  • Albuterol