Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats

Behav Neurosci. 1998 Dec;112(6):1450-7. doi: 10.1037//0735-7044.112.6.1450.

Abstract

This study compared the interaction of strain with isolation rearing on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis, Sprague-Dawley, and Fischer F344 rats tested as adults. Lewis and Fischer rats exhibited lower startle reactivity than Sprague-Dawley rats. Lewis rats displayed more rapid habituation than the other strains. Most important, isolation rearing produced deficits in PPI in both Sprague-Dawley and Fischer rats but had no effect in Lewis rats. By contrast, isolation rearing had no effect on startle reactivity or habituation. In a separate study, 0.5 mg/kg apomorphine disrupted PPI in Fischer but not in Lewis rats. Thus, PPI in Lewis rats is relatively unaffected by either a pharmacological or a developmental manipulation, both of which disrupt PPI in Sprague-Dawley and Fischer F344 rats.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arousal / genetics*
  • Genotype*
  • Habituation, Psychophysiologic / genetics*
  • Inhibition, Psychological*
  • Male
  • Neuronal Plasticity / genetics
  • Rats
  • Rats, Inbred F344
  • Rats, Inbred Lew
  • Rats, Sprague-Dawley
  • Reflex, Startle*
  • Social Isolation*
  • Species Specificity