Even moderate cigarette smoking influences the pattern of circulating monocytes and the concentration of sICAM-1

Respir Physiol. 1998 Dec;114(3):269-75. doi: 10.1016/s0034-5687(98)00098-x.


The pattern of circulating monocyte subtypes and the concentration of the soluble intercellular adhesion molecule-1 (ICAM-1) were compared in middle-aged female moderate smokers and lifetime non-smokers. Total leukocyte and monocyte counts were higher in smokers. The pattern of circulating monocytes of smokers was changed toward lower absolute counts of activated (CD16+/CD64+) monocytes and (CD16+/CD14+) monocyte-macrophages and higher counts of nonactivated monocytes. The serum concentration of soluble ICAM-1 was significantly higher in smokers than in non-smokers. It is supposed that even moderate cigarette smoking leads to an activation of the circulating monocytes and their increased adhesion to the endothelium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / immunology
  • Cell Adhesion / drug effects
  • Female
  • Hematologic Tests
  • Humans
  • Intercellular Adhesion Molecule-1 / blood*
  • Leukocytes / metabolism
  • Lymphocytes / metabolism
  • Middle Aged
  • Monocytes / classification
  • Monocytes / metabolism*
  • Smoking / adverse effects*
  • Smoking / blood


  • Antigens, CD
  • Intercellular Adhesion Molecule-1