Behavioral and electrophysiological analysis of Ca-activated K-channel transgenes in Drosophila

Ann N Y Acad Sci. 1998 Nov 16;860:296-305. doi: 10.1111/j.1749-6632.1998.tb09057.x.

Abstract

The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing. We have described in great depth how transcription is regulated and are now cataloging the tissue-specificity of different splice variants. It is believed that the diversity of products serves to tailor channel attributes to the needs of specific tissues. Electrophysiological and behavioral assays indicate that at least some of these products produce channels with distinct properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Calcium / metabolism*
  • Drosophila / genetics*
  • Drosophila Proteins
  • Electrophysiology
  • Large-Conductance Calcium-Activated Potassium Channels
  • Neurons / chemistry
  • Neurons / metabolism
  • Potassium Channels / genetics*
  • Potassium Channels / metabolism*
  • Potassium Channels, Calcium-Activated*
  • Transgenes / physiology

Substances

  • Drosophila Proteins
  • Large-Conductance Calcium-Activated Potassium Channels
  • Potassium Channels
  • Potassium Channels, Calcium-Activated
  • slo protein, Drosophila
  • Calcium