Experimental models to study molecular mechanisms underlying intestinal inflammation

Ann N Y Acad Sci. 1998 Nov 17;859:85-95. doi: 10.1111/j.1749-6632.1998.tb11113.x.


Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / physiology
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Mucosal
  • Inflammation
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / physiopathology*
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred Strains
  • Receptors, Cytokine / physiology
  • T-Lymphocytes / physiology


  • Cytokines
  • Receptors, Cytokine