Several studies note that the relative risk of injury for physically challenged athletes is approximately the same as that of nondisabled athletes. Since the 1940s physically challenged athletes have increasingly competed on national and international levels. This chapter describes sport-specific adaptations (such as a prosthesis or wheelchair), classifies the suitability of sports activities according to disability, and outlines measures to prevent injury in disabled athletes. The author also includes a resource list of publications, organizations, and web sites for disabled athletes.