Comparative DNA analysis across diverse genomes

Annu Rev Genet. 1998;32:185-225. doi: 10.1146/annurev.genet.32.1.185.


We review concepts and methods for comparative analysis of complete genomes including assessments of genomic compositional contrasts based on dinucleotide and tetranucleotide relative abundance values, identifications of rare and frequent oligonucleotides, evaluations and interpretations of codon biases in several large prokaryotic genomes, and characterizations of compositional asymmetry between the two DNA strands in certain bacterial genomes. The discussion also covers means for identifying alien (e.g. laterally transferred) genes and detecting potential specialization islands in bacterial genomes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / genetics
  • Base Composition
  • Base Sequence
  • Codon / genetics
  • DNA / chemistry
  • DNA / genetics*
  • DNA, Bacterial / genetics
  • Eukaryotic Cells
  • Genome*
  • Genome, Bacterial
  • Prokaryotic Cells
  • Species Specificity


  • Codon
  • DNA, Bacterial
  • DNA