[The efficacy of the polyphenol plant preparation piflamin in drug damage to the liver]

L V Iakovleva; N D Buniatian; O A Gerasimova; V V Chikitkina; A M Kovaleva

[The efficacy of the polyphenol plant preparation piflamin in drug damage to the liver]

Eksp Klin Farmakol. 1998 Nov-Dec;61(6):48-50.

[Article in Russian]

Authors

L V Iakovleva¹, N D Buniatian, O A Gerasimova, V V Chikitkina, A M Kovaleva

Affiliation

¹ Central Research Laboratory, Ukranian Pharmaceutical Academy, Kharkov, Ukraine.

PMID: 9929818

Abstract

The hepatoprotective properties of the flavonoid preparation piflamine of field-peas grass were studied on a model of experimental paracetamol liver damage. Piflamine was found to normalize the parameters of carbohydrate, protein, and lipid metabolism, increase the activity of the antioxidant system, and restore the processes of bile production and bile secretion. The drug is prospective due to its quite cheap and available source of raw materials.

Publication types

Comparative Study

MeSH terms

Acetaminophen / toxicity
Analgesics, Non-Narcotic / toxicity
Animals
Antioxidants / therapeutic use*
Chemical and Drug Induced Liver Injury / drug therapy*
Chemical and Drug Induced Liver Injury / enzymology
Chemical and Drug Induced Liver Injury / etiology
Drug Evaluation, Preclinical
Flavonoids / therapeutic use*
Liver / drug effects
Liver / enzymology
Male
Phenols / therapeutic use*
Pisum sativum*
Plant Extracts / therapeutic use
Rats
Tablets

Substances

Analgesics, Non-Narcotic
Antioxidants
Flavonoids
Phenols
Plant Extracts
Tablets
silibor
Acetaminophen