Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system

Neuroimage. 1999 Feb;9(2):195-207. doi: 10.1006/nimg.1998.0396.


The surface of the human cerebral cortex is a highly folded sheet with the majority of its surface area buried within folds. As such, it is a difficult domain for computational as well as visualization purposes. We have therefore designed a set of procedures for modifying the representation of the cortical surface to (i) inflate it so that activity buried inside sulci may be visualized, (ii) cut and flatten an entire hemisphere, and (iii) transform a hemisphere into a simple parameterizable surface such as a sphere for the purpose of establishing a surface-based coordinate system.

MeSH terms

  • Artifacts
  • Brain Mapping / instrumentation
  • Cerebral Cortex / anatomy & histology*
  • Dominance, Cerebral / physiology
  • Humans
  • Image Processing, Computer-Assisted / instrumentation*
  • Magnetic Resonance Imaging / instrumentation*
  • Software