Bilateral ocular ischemic syndrome secondary to giant cell arteritis progressing despite corticosteroid treatment

Am J Ophthalmol. 1999 Jan;127(1):102-4. doi: 10.1016/s0002-9394(98)00313-4.


Purpose: To report the development of a bilateral ocular ischemic syndrome despite corticosteroid treatment in a patient with giant cell arteritis.

Method: Case report.

Results: Despite receiving high-dose intravenous methylprednisolone and oral prednisone for biopsy-proven giant cell arteritis that presented as a severe anterior ischemic optic neuropathy in the right eye, a patient developed progressive ocular ischemia in that eye as well as an ocular ischemic syndrome in the fellow eye.

Conclusions: Some patients with giant cell arteritis, possibly patients with other underlying systemic vasculopathies, are refractory to what should be adequate treatment with systemic corticosteroids and may develop a bilateral ocular ischemic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Blindness / etiology
  • Blindness / physiopathology
  • Disease Progression
  • Eye / blood supply*
  • Female
  • Giant Cell Arteritis / complications*
  • Giant Cell Arteritis / drug therapy
  • Giant Cell Arteritis / physiopathology
  • Humans
  • Infusions, Intravenous
  • Ischemia / etiology*
  • Ischemia / pathology
  • Ischemia / physiopathology
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / therapeutic use*
  • Optic Neuropathy, Ischemic / etiology
  • Prednisone / administration & dosage
  • Prednisone / therapeutic use*
  • Syndrome
  • Temporal Arteries / pathology
  • Visual Acuity


  • Prednisone
  • Methylprednisolone