Circulating cytokine balance and activation markers of leucocytes in Q fever

Clin Exp Immunol. 1999 Jan;115(1):120-3. doi: 10.1046/j.1365-2249.1999.00786.x.


As Q fever is associated with an inflammatory syndrome, we determined circulating levels of inflammatory cytokines, cytokine antagonists, and activation markers of leucocytes in patients with acute Q fever and Q fever endocarditis. Tumour necrosis factor (TNF) and IL-6, but not IL-1beta, were markedly increased compared with controls. Cytokine antagonists and activation markers of leucocytes were profoundly different in acute and chronic Q fever. IL-1 receptor antagonist and TNF receptor type II were significantly increased in patients with acute Q fever, suggesting a shift of cytokine balance towards cytokine antagonists. The activation marker of B cells, sCD23, was significantly increased in Q fever endocarditis compared with controls and patients with acute Q fever. In a 2-year follow-up study of patients with Q fever endocarditis, sCD23 and specific IgG levels slowly decreased in patients whose symptoms resolved, but remained high in those who required prolonged treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Cytokines / blood*
  • Endocarditis, Bacterial / blood
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Leukocytes / chemistry*
  • Lipopolysaccharide Receptors / blood
  • Male
  • Middle Aged
  • Neopterin / blood
  • Q Fever / blood*
  • Receptors, IgE / blood
  • Sialoglycoproteins / blood
  • Solubility
  • Up-Regulation / physiology


  • Biomarkers
  • Cytokines
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Lipopolysaccharide Receptors
  • Receptors, IgE
  • Sialoglycoproteins
  • Neopterin