Positron emission tomographic assessment of "metabolic flare" to predict response of metastatic breast cancer to antiestrogen therapy

Eur J Nucl Med. 1999 Jan;26(1):51-6. doi: 10.1007/s002590050359.


We have investigated whether increased tumor uptake of fluorine-18 fluorodeoxyglucose (FDG) detected with positron emission tomography (PET) early after initiating tamoxifen therapy ("metabolic flare") predicts a hormonally responsive breast cancer. Eleven postmenopausal women with biopsy-proved estrogen receptor-positive (ER+) metastatic breast cancer were studied by PET with FDG and 16alpha[18F]fluoro-17beta-estradiol (FES) before and 7-10 days after initiation of tamoxifen therapy. FDG and FES uptake was evaluated semiquantitatively in 21 lesions. The PET results were correlated with follow-up evaluation, continued until the patient became unresponsive to hormone therapy (3-24 months). There were seven responders and four nonresponders based on clinical follow-up. None of the responders had a clinical flare reaction, but all demonstrated metabolic flare, with a mean +/- standard deviation increase in tumor standardized uptake value (SUV) for FDG of 1.4+/-0. 7. No evidence for flare was noted in the nonresponders (change in SUV for FDG -0.1+/-0.4; P = 0.008 vs. responders). The degree of ER blockade by tamoxifen was greater in responders (mean decrease in SUV 2.7+/-1.7) than in nonresponders (mean decrease 0.8+/-0.5) (P = 0.04). The lesions of responders had higher baseline SUVs for FES than did those of three of four nonresponders (>/=2.2 vs </=1.7). The findings of a metabolic flare by FDG-PET and the degree of ER blockade by FES-PET early after institution of tamoxifen treatment appear to predict responsiveness to antiestrogen therapy in patients with ER+ metastatic breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Estradiol / analogs & derivatives
  • Estrogen Antagonists / therapeutic use*
  • Female
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Follow-Up Studies
  • Humans
  • Predictive Value of Tests
  • Radiopharmaceuticals
  • Receptors, Estrogen / analysis
  • Tamoxifen / therapeutic use*
  • Time Factors
  • Tomography, Emission-Computed*
  • Treatment Outcome


  • Antineoplastic Agents, Hormonal
  • Estrogen Antagonists
  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Estrogen
  • Tamoxifen
  • Fluorodeoxyglucose F18
  • Estradiol
  • 16-fluoroestradiol