Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3589-94. doi: 10.1016/s0960-894x(98)00652-0.

Abstract

A series of styrylpyridine derivatives containing two phenols was prepared via an efficient two-step synthesis. These compounds were designed to maximize the estrogen receptor binding affinity of a known series of inherently fluorescent styrylpyridines. While significant improvements were achieved in receptor affinity, the fluorescence intensity of this series of compounds is poor.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / metabolism
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Protein Binding
  • Pyridines / chemical synthesis*
  • Pyridines / metabolism
  • Receptors, Estrogen / metabolism*
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Ligands
  • Pyridines
  • Receptors, Estrogen