Abstract
A series of trisubstituted hydantoins has been prepared by a versatile solid phase route employing primary alcohols, amines and amino acids as the monomeric building blocks. Several compounds showed submicromolar affinity in binding assays at recombinant human somatostatin receptors.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Humans
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Hydantoins / chemistry
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Hydantoins / metabolism*
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Iodine Radioisotopes
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Ligands
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Radioligand Assay
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Receptors, Somatostatin / metabolism*
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Recombinant Proteins / metabolism
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Somatostatin / analogs & derivatives
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Somatostatin / metabolism
Substances
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Hydantoins
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Iodine Radioisotopes
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Ligands
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Receptors, Somatostatin
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Recombinant Proteins
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Somatostatin
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somatostatin, iodo-Tyr(1)-
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somatostatin receptor 5