Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3659-64. doi: 10.1016/s0960-894x(98)00671-4.

Abstract

Truncated analogs of tripterine as cytokine (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8) release inhibitors are discussed.

MeSH terms

  • Cells, Cultured
  • Humans
  • Interleukins / antagonists & inhibitors*
  • Interleukins / metabolism
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Pentacyclic Triterpenes
  • Structure-Activity Relationship
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Interleukins
  • Pentacyclic Triterpenes
  • Triterpenes
  • Tumor Necrosis Factor-alpha
  • celastrol