Purpose: The usefulness of a single intraoperative application of mitomycin C was investigated in repeat dacryocystorhinostomy for membranous failure.
Methods: Mitomycin C (0.3 mg/ml for 3 minutes) was topically applied to the fistula site in eight patients undergoing repeat dacryocystorhinostomy for membranous failure.
Results: All patients remain asymptomatic and anatomic patency confirmed by probe and irrigation with a mean follow-up period of 14.6 months (range, 6-26 months). No postoperative complications associated with the use of mitomycin C were observed.
Conclusions: In patients who do not maintain a patent fistula after dacryocystorhinostomy because of membranous occlusion of the rhinostomy site, the adjunctive use of mitomycin C may increase the success rate of repeat dacryocystorhinostomy.