Feverfew as a preventive treatment for migraine: a systematic review

Cephalalgia. 1998 Dec;18(10):704-8. doi: 10.1046/j.1468-2982.1998.1810704.x.


Background: Feverfew is a popular herbal remedy advocated for the prevention of migraine.

Aim: The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention.

Data sources: Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998).

Study selection: Only randomized, placebo-controlled, double-blind trials were included.

Data extraction: All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score.

Main results: Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist.

Conclusion: The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Humans
  • Migraine Disorders / prevention & control*
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal
  • Randomized Controlled Trials as Topic
  • Sesquiterpenes / therapeutic use*
  • Tanacetum parthenium


  • Plant Extracts
  • Sesquiterpenes