Association of clinical manifestations with HLA-B alleles in Takayasu arteritis

Int J Cardiol. 1998 Oct 1:66 Suppl 1:S121-6. doi: 10.1016/s0167-5273(98)00159-4.


HLA-DNA typing using PCR-SSOP and PCR-DCP methods was performed in 85 patients with Takayasu arteritis and 492 healthy controls who had been typed for HLA by serological method. Frequencies of HLA-B52 (B*5201) and B39 (B*3901 and B*3902) were significantly increased in the patients. Frequency of HLA-DRB1*1502 was also increased but it was suggested to be a reflection of its linkage disequilibrium with B52. Association of HLA-B52 and B39 with seven clinical manifestations--pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-)-B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. On the other hand, in HLA-B39 positive TA patients, frequency of renal artery stenosis was significantly increased (vs B52(+)-B39(-), OR=12.14, P<0.001, vs B52(-)-B39(-), OR=5.21, P<0.03). These observations have suggested that HLA-B52 molecule and B39 molecule would contribute to different clinical manifestations by binding different antigenic peptides to cause inflammations. Thus HLA-B molecule may play an important role in pathogenesis or determining clinical manifestations of Takayasu arteritis.

Publication types

  • Comparative Study

MeSH terms

  • Alleles
  • DNA / analysis
  • DNA Primers / chemistry
  • Female
  • Gene Frequency
  • HLA-B Antigens / genetics*
  • HLA-B39 Antigen
  • HLA-B52 Antigen
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Histocompatibility Testing
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Takayasu Arteritis / diagnosis
  • Takayasu Arteritis / genetics*


  • DNA Primers
  • HLA-B Antigens
  • HLA-B39 Antigen
  • HLA-B52 Antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • DNA