Mosaic Organization of DNA Nucleotides

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994 Feb;49(2):1685-9. doi: 10.1103/physreve.49.1685.

Abstract

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations. Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacteriophage lambda
  • Base Sequence
  • Chromosome Walking*
  • DNA / chemistry*
  • DNA, Bacterial
  • DNA, Viral
  • Escherichia coli
  • Exons
  • Humans
  • Introns*
  • Nucleotide Mapping*
  • Receptors, Antigen, T-Cell / genetics
  • Sequence Analysis, DNA / statistics & numerical data*

Substances

  • DNA, Bacterial
  • DNA, Viral
  • Receptors, Antigen, T-Cell
  • DNA