Exencephaly in fetal hamsters following exposure to hyperthermia

Teratology. 1976 Dec;14(3):323-6. doi: 10.1002/tera.1420140307.


Exposure of pregnant hamsters on gestation day 8 to 40 or 41 degrees C for one hour caused an increased rate of resorption and a high frequency of exencephaly and encephalocele. Longer exposures often killed pregnant females. Hamsters that had fetuses with abnormalities usually experienced body temperature elevations of 3-4 degrees C above normal (37 degrees C).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / abnormalities*
  • Congenital Abnormalities / etiology*
  • Cricetinae
  • Encephalocele / etiology
  • Female
  • Fever / complications*
  • Gestational Age
  • Pregnancy
  • Stress, Physiological / complications