Abstract
Two antimicrobial substances in rice hull were isolated and identified as 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid by LC-MS, and 1H- and 13C-NMR. An evaluation of 50% inhibition of growth (IC50) revealed that the two substances had different inhibition profiles against various microorganisms. Most of the gram-positive and some gram-negative bacteria were sensitive to trans 4-hydroxycinnamic acid and 4-hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 micrograms/ml, respectively.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / isolation & purification
-
Anti-Bacterial Agents / pharmacology*
-
Biological Assay
-
Coumaric Acids / isolation & purification
-
Coumaric Acids / pharmacology*
-
Gram-Negative Bacteria / drug effects
-
Gram-Positive Bacteria / drug effects
-
Molecular Weight
-
Oryza / chemistry*
-
Parabens / isolation & purification
-
Parabens / pharmacology*
-
Propionates
-
Stereoisomerism
Substances
-
Anti-Bacterial Agents
-
Coumaric Acids
-
Parabens
-
Propionates
-
p-coumaric acid
-
4-hydroxybenzoic acid