Antimicrobial activity of 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid isolated and identified from rice hull

Biosci Biotechnol Biochem. 1998 Nov;62(11):2273-6. doi: 10.1271/bbb.62.2273.

Abstract

Two antimicrobial substances in rice hull were isolated and identified as 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid by LC-MS, and 1H- and 13C-NMR. An evaluation of 50% inhibition of growth (IC50) revealed that the two substances had different inhibition profiles against various microorganisms. Most of the gram-positive and some gram-negative bacteria were sensitive to trans 4-hydroxycinnamic acid and 4-hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 micrograms/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Biological Assay
  • Coumaric Acids / isolation & purification
  • Coumaric Acids / pharmacology*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Molecular Weight
  • Oryza / chemistry*
  • Parabens / isolation & purification
  • Parabens / pharmacology*
  • Propionates
  • Stereoisomerism

Substances

  • Anti-Bacterial Agents
  • Coumaric Acids
  • Parabens
  • Propionates
  • p-coumaric acid
  • 4-hydroxybenzoic acid