Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

Comp Biochem Physiol B Biochem Mol Biol. 1998 Sep;121(1):19-26. doi: 10.1016/s0305-0491(98)10106-2.


The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • GRB10 Adaptor Protein
  • GRB2 Adaptor Protein
  • Humans
  • Inositol Phosphates / physiology
  • Models, Biological
  • Multigene Family
  • Nuclear Proteins / physiology
  • Phosphoproteins / physiology
  • Phosphorylation
  • Protein Kinases / physiology
  • Protein Serine-Threonine Kinases*
  • Proteins / physiology
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-crk
  • Receptor, IGF Type 1 / genetics
  • Receptor, IGF Type 1 / physiology*
  • Receptor, Insulin / genetics
  • Receptor, Insulin / physiology
  • Signal Transduction / physiology*


  • Adaptor Proteins, Signal Transducing
  • CRKL protein
  • GRB2 Adaptor Protein
  • GRB2 protein, human
  • Inositol Phosphates
  • Nuclear Proteins
  • Phosphoproteins
  • Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-crk
  • GRB10 Adaptor Protein
  • Protein Kinases
  • Receptor, IGF Type 1
  • Receptor, Insulin
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt