Inability of bone turnover marker as a strong prognostic indicator in prostate cancer patients with bone metastasis: comparison with the extent of disease (EOD) grade

Prostate. 1999 Jan 1;38(1):28-34. doi: 10.1002/(sici)1097-0045(19990101)38:1<28::aid-pros3>;2-m.


Background: Although clinical investigations of bone turnover markers in prostate cancer patients have been conducted, the relationships of pretreatment levels of the markers to the prognosis of patients with bone metastasis has not been fully examined.

Methods: The serum levels of carboxy-terminal propeptide of type I procollagen (PICP) and carboxy-terminal telopeptide of type I collagen (ICTP), alkaline phosphatase (ALP), and prostate-specific antigen (PSA) were examined in 48 untreated prostate cancer patients with bone metastasis, and the prognoses of the patients were evaluated using univariate and multivariate analyses.

Results: The patients with low PICP or ALP values had significantly better outcomes in terms of cause-specific survival compared to the patients with high PICP or ALP values. There was no significant difference in survival between patients with high and low ICTP or PSA values. The multivariate analysis of PICP, ICTP, ALP, PSA, and extent of disease (EOD) grade revealed that only the EOD grade was an important prognostic indicator for survival.

Conclusions: These results demonstrate that the extent of bone metastasis evaluated by bone scintigrams is a more important prognostic indicator than are the serum biochemical markers of bone turnover.

MeSH terms

  • Aged
  • Alkaline Phosphatase / blood
  • Biomarkers*
  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / secondary*
  • Collagen / blood
  • Collagen Type I
  • Colorimetry
  • Humans
  • Male
  • Multivariate Analysis
  • Peptide Fragments / blood
  • Peptides / blood
  • Procollagen / blood
  • Prognosis
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery
  • Radioimmunoassay
  • Treatment Outcome


  • Biomarkers
  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • procollagen type I carboxy terminal peptide
  • Collagen
  • Alkaline Phosphatase
  • Prostate-Specific Antigen