Circulating interleukin-16 in systemic lupus erythematosus

Br J Rheumatol. 1998 Dec;37(12):1334-7. doi: 10.1093/rheumatology/37.12.1334.


Objective: To investigate the relationship between interleukin (IL)-16 and systemic lupus erythematosus (SLE).

Methods: Serum levels of IL-16 were examined in SLE patients using an enzyme-linked immunosorbent assay (ELISA).

Results: The serum level of IL-16 in the patients was much higher than that in healthy volunteers (P < 0.001). An increase in IL-16 was observed in proportion to the activity of SLE assessed by the SLE Disease Activity Index (SLEDAI) score (P < 0.0001).

Conclusions: Our observations suggest an interaction between disease activity and the production of IL-16 in SLE, and reveal that IL-16 is a useful indicator of disease activity. This is the first report describing the relationship between IL-16 and SLE.

MeSH terms

  • Adolescent
  • Adult
  • CD4-Positive T-Lymphocytes / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-16 / blood*
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged


  • Interleukin-16