Risk of a new benzodiazepine prescription in relation to recent hospitalization

J Am Geriatr Soc. 1999 Feb;47(2):184-8. doi: 10.1111/j.1532-5415.1999.tb04576.x.


Objective: To determine if recent hospital admission was associated with new outpatient prescribing of benzodiazepines among community-dwelling older people.

Design: Nested case-control study using administrative data sets of the provincial health insurance board.

Setting: Province of Quebec.

Participants: Cases were 4127 community-dwelling older people who were newly dispensed a benzodiazepine during an 8-month period in 1990. Controls were 16,486 community-dwelling older people who were dispensed any drug (except a benzodiazepine) on the same day as the case-defining index prescription. EXPOSURE AND OUTCOME MEASURES: Admission to an acute care hospital within a 30-day period before a new dispensing of a benzodiazepine. Other variables measured were patient age, gender, number of ambulatory physician visits, healthcare region, Chronic Disease Score (CDS), and use of drugs for depression and psychosis.

Results: Cases were more than three times as likely as controls to have been hospitalized in the 30-day period before the index date (adjusted odds ratio (OR) 3.09; 95% CI, 2.78-3.45). The use of prescription drugs for physical health problems modified this association in that cases who used more medication were also more likely to receive a new benzodiazepine prescription following a recent hospital admission (adjusted OR 4.09; 95% CI, 3.59-4.65 when the CDS was equal to 5 vs adjusted OR 1.96; 95% CI, 1.66-2.31 when the CDS was equal to 0).

Conclusions: Recent hospitalization confers an increased risk of a new outpatient benzodiazepine prescription among community-dwelling older people in Quebec. Those who use more medication, and who may be more vulnerable to drug-related adverse events, are more likely to be newly dispensed a benzodiazepine following a recent, acute-care hospital admission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Ambulatory Care / statistics & numerical data
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / therapeutic use*
  • Benzodiazepines
  • Case-Control Studies
  • Cohort Studies
  • Drug Prescriptions / statistics & numerical data*
  • Drug Utilization
  • Female
  • Humans
  • Male
  • Patient Discharge / statistics & numerical data*
  • Quebec
  • Risk


  • Anti-Anxiety Agents
  • Benzodiazepines