Abstract
Adapalene and tretinoin are molecules used in the topical treatment of acne vulgaris. Commercial formulations (adapalene 0.1% gel and tretinoin 0.025% gel) were mixed with equal volumes of commercially available benzoyl peroxide formulation (10% lotion) and subsequently exposed to light over 24 h. With and without exposition to light, adapalene exhibits a remarkable stability whereas tretinoin is very sensitive to light and oxidation. The combination of benzoyl peroxide and light results in more than 50% degradation of tretinoin in about 2 h and 95% in 24 h.
MeSH terms
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Adapalene
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / radiation effects*
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Benzoyl Peroxide / chemistry
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Benzoyl Peroxide / radiation effects*
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Chromatography, High Pressure Liquid
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Drug Combinations
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Drug Stability
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Gels
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Keratolytic Agents / chemistry
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Keratolytic Agents / radiation effects*
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Light*
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Naphthalenes / chemistry
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Naphthalenes / radiation effects*
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Tretinoin / chemistry
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Tretinoin / radiation effects*
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Ultraviolet Rays*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Drug Combinations
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Gels
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Keratolytic Agents
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Naphthalenes
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Adapalene
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Tretinoin
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Benzoyl Peroxide