The advent of highly selective inhibitors of cyclooxygenase--a review

Prostaglandins Other Lipid Mediat. 1998 Aug;56(5-6):341-61. doi: 10.1016/s0090-6980(98)00064-1.

Abstract

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2, COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenoma / chemistry
  • Blood Platelets / physiology
  • Colorectal Neoplasms / chemistry
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors / metabolism*
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Digestive System Physiological Phenomena
  • Dose-Response Relationship, Drug
  • Humans
  • Inflammation / metabolism
  • Isoenzymes / physiology*
  • Kidney / physiology
  • Membrane Proteins
  • Models, Biological
  • Prostaglandin-Endoperoxide Synthases / physiology*
  • Prostaglandins / metabolism
  • Protein Isoforms / physiology

Substances

  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Membrane Proteins
  • Prostaglandins
  • Protein Isoforms
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • PTGS1 protein, human
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases