A structural comparison of molybdenum cofactor-containing enzymes

FEMS Microbiol Rev. 1998 Dec;22(5):503-21. doi: 10.1111/j.1574-6976.1998.tb00384.x.

Abstract

This work gives an overview of the recent achievements which have contributed to the understanding of the structure and function of molybdenum and tungsten enzymes. Known structures of molybdo-pterin cofactor-containing enzymes will be described briefly and the structural differences between representatives of the same and different families will be analyzed. This comparison will show that the molybdo-pterin cofactor-containing enzymes represent a very heterogeneous group with differences in overall enzyme structure, cofactor composition and stoichiometry, as well as differences in the immediate molybdenum environment. Two recently discovered molybdo-pterin cofactor-containing enzymes will be described with regard to molecular and EPR spectroscopic properties, pyrogallol-phloroglucinol transhydroxylase from Pelobacter acidigallici and acetylene hydratase from Pelobacter acetylenicus. On the basis of its amino acid sequence, transhydroxylase can be classified as a member of the dimethylsulfoxide reductase family, whereas classification of the tungsten/molybdenum-containing acetylene hydratase has to await the determination of its amino acid sequence.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria, Anaerobic / enzymology*
  • Coenzymes / chemistry
  • Humans
  • Hydro-Lyases / chemistry*
  • Metalloproteins / chemistry*
  • Mixed Function Oxygenases / chemistry*
  • Molybdenum Cofactors
  • Molybdenum*
  • Oxidoreductases / chemistry*
  • Oxidoreductases Acting on Sulfur Group Donors / chemistry
  • Pteridines / chemistry*
  • Tungsten / chemistry
  • Xanthine Oxidase / chemistry

Substances

  • Coenzymes
  • Metalloproteins
  • Molybdenum Cofactors
  • Pteridines
  • Molybdenum
  • molybdenum cofactor
  • Mixed Function Oxygenases
  • Oxidoreductases
  • Xanthine Oxidase
  • Oxidoreductases Acting on Sulfur Group Donors
  • Hydro-Lyases
  • acetylene hydratase
  • Tungsten

Associated data

  • GENBANK/AJ243850