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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1970 2
1972 1
1975 1
1977 1
1979 1
1981 1
1982 1
1984 4
1986 3
1989 1
1990 1
1991 3
1994 1
1997 1
1998 1
1999 2
2001 1
2004 2
2005 3
2006 1
2008 1
2009 2
2011 1
2012 1
2014 1
2017 1
2019 1
2021 0
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41 results
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Page 1
Effect of Caffeine on the Bioavailability and Pharmacokinetics of an Acetylsalicylic Acid-Paracetamol Combination: Results of a Phase I Study.
Weiser T, Weigmann H. Weiser T, et al. Adv Ther. 2019 Mar;36(3):597-607. doi: 10.1007/s12325-019-0891-5. Epub 2019 Feb 13. Adv Ther. 2019. PMID: 30758744 Free PMC article. Clinical Trial.
The present study aimed to determine the effect of caffeine on the pharmacokinetics of acetylsalicylic acid (ASA) and paracetamol when used as a fixed-dose ASA/paracetamol/caffeine combination. METHODS: In this single-centre, two-way, cross-over phase …
The present study aimed to determine the effect of caffeine on the pharmacokinetics of acetylsalicylic acid (ASA) and paracetamol
Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.
Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J. Goldstein J, et al. Headache. 2005 Sep;45(8):973-82. doi: 10.1111/j.1526-4610.2005.05177.x. Headache. 2005. PMID: 16109110 Clinical Trial.
METHODS: We compared a combination of nonprescription migraine medication (acetaminophen 500 mg, aspirin 500 mg, and caffeine 130 mg) with a prescription migraine product (50 mg sumatriptan) in a randomized, controlled clinical trial in which subjects treated …
METHODS: We compared a combination of nonprescription migraine medication (acetaminophen 500 mg, aspirin 500 mg, and caffei
Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials.
Lipton RB, Stewart WF, Ryan RE Jr, Saper J, Silberstein S, Sheftell F. Lipton RB, et al. Arch Neurol. 1998 Feb;55(2):210-7. doi: 10.1001/archneur.55.2.210. Arch Neurol. 1998. PMID: 9482363 Clinical Trial.
OBJECTIVE: To assess the effectiveness of the nonprescription combination of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain. ...INTERVENTION: Two tablets of the nonprescription combination of acetaminophen, aspirin, a …
OBJECTIVE: To assess the effectiveness of the nonprescription combination of acetaminophen, aspirin, and caffeine in al …
Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study.
Goldstein J, Silberstein SD, Saper JR, Ryan RE Jr, Lipton RB. Goldstein J, et al. Headache. 2006 Mar;46(3):444-53. doi: 10.1111/j.1526-4610.2006.00376.x. Headache. 2006. PMID: 16618262 Clinical Trial.
OBJECTIVE: Compare the effectiveness of a combination analgesic containing acetaminophen, aspirin, and caffeine to that of ibuprofen in the treatment of migraine. ...A single 2-tablet dose for each of the 3 treatment groups: a combination product containing …
OBJECTIVE: Compare the effectiveness of a combination analgesic containing acetaminophen, aspirin, and caffeine to that …
Efficacy of low dose combination analgesics: acetaminophen/codeine, aspirin/butalbital/caffeine/codeine, and placebo in oral surgery pain.
Desjardins PJ, Cooper SA, Finizio T. Desjardins PJ, et al. Anesth Prog. 1986 May-Jun;33(3):143-6. Anesth Prog. 1986. PMID: 3461726 Free PMC article. Clinical Trial.
The aspirin/butalbital/caffeine/codeine combination was numerically superior to acetaminophen/codeine for every measure of analgesic efficacy but the differences did not achieve statistical significance. ...The adverse effects occurred equally among the three …
The aspirin/butalbital/caffeine/codeine combination was numerically superior to acetaminophen/codeine for every measure …
A double-blind randomized study of an aspirin/caffeine combination versus acetaminophen/aspirin combination versus acetaminophen versus placebo in patients with moderate to severe post-partum pain.
Rubin A, Winter L Jr. Rubin A, et al. J Int Med Res. 1984;12(6):338-45. doi: 10.1177/030006058401200604. J Int Med Res. 1984. PMID: 6519349 Free article. Clinical Trial.
In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an aspirin/caffeine combination (800 mg aspirin, 65 mg caffeine) provided significantly more pain relief at 2 hour …
In a double-blind, randomized controlled trial among 500 post-partum patients experiencing moderate to severe pain, a single oral dose of an …
The efficacy and tolerability of a fixed combination of acetylsalicylic acid, paracetamol, and caffeine in patients with severe headache: a post-hoc subgroup analysis from a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study.
Diener HC, Peil H, Aicher B. Diener HC, et al. Cephalalgia. 2011 Oct;31(14):1466-76. doi: 10.1177/0333102411419682. Epub 2011 Sep 9. Cephalalgia. 2011. PMID: 21908446 Clinical Trial.
BACKGROUND: We investigated efficacy and tolerability of two tablets of the fixed combination of 250 mg acetylsalicylic acid (ASA) + 200 mg paracetamol + 50 mg caffeine (Thomapyrin) in comparison to two tablets of placebo in a post-hoc analysis of a subgroup of pati …
BACKGROUND: We investigated efficacy and tolerability of two tablets of the fixed combination of 250 mg acetylsalicylic acid (ASA) + 200 mg …
Analgesic effect of an aspirin-codeine-butalbital-caffeine combination and an acetaminophen-codeine combination in postoperative oral surgery pain.
Forbes JA, Jones KF, Smith WK, Gongloff CM. Forbes JA, et al. Pharmacotherapy. 1986 Sep-Oct;6(5):240-7. doi: 10.1002/j.1875-9114.1986.tb03483.x. Pharmacotherapy. 1986. PMID: 3540875 Clinical Trial.
The efficacy of an aspirin-caffeine-codeine-butalbital combination was compared to an acetaminophen-codeine combination and placebo in outpatients who had moderate or severe pain after the surgical removal of impacted third molars. ...Although the butalbital- …
The efficacy of an aspirin-caffeine-codeine-butalbital combination was compared to an acetaminophen-codeine combination …
Effect of prophylactic administration of Novafen for periodontal surgery on postoperative pain relief.
Kashefimehr A, Babaloo A, Ghanizadeh M, Ghasemi SH, Mollazadeh H. Kashefimehr A, et al. J Med Life. 2017 Apr-Jun;10(2):127-130. J Med Life. 2017. PMID: 28616088 Free PMC article. Clinical Trial.
One of the most commonly used medications for pain control is Ibuprofen, which is one of the NSAIDs and is a simple derivative of phenylpropionic acid. There is evidence that caffeine alone or in association with Acetaminophen, Ibuprofen, or Aspirin can incre …
One of the most commonly used medications for pain control is Ibuprofen, which is one of the NSAIDs and is a simple derivative of phenylprop …
Caffeine as an analgesic adjuvant in tension headache.
Migliardi JR, Armellino JJ, Friedman M, Gillings DB, Beaver WT. Migliardi JR, et al. Clin Pharmacol Ther. 1994 Nov;56(5):576-86. doi: 10.1038/clpt.1994.179. Clin Pharmacol Ther. 1994. PMID: 7955822 Clinical Trial.
In four studies, comprising 1900 patients, the caffeine-containing analgesic consisted of a combination of 500 mg acetaminophen, 500 mg aspirin, and 130 mg caffeine (APAP/ASA/CAF). In two studies, comprising 911 patients, the caffeine-containing …
In four studies, comprising 1900 patients, the caffeine-containing analgesic consisted of a combination of 500 mg acetaminophen
41 results