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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
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1972 1
1975 1
1977 1
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1981 1
1982 1
1984 4
1986 3
1989 1
1990 1
1991 3
1994 1
1997 1
1998 1
1999 2
2001 1
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2005 3
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2009 2
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41 results

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Page 1
Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.
Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J. Goldstein J, et al. Headache. 2005 Sep;45(8):973-82. doi: 10.1111/j.1526-4610.2005.05177.x. Headache. 2005. PMID: 16109110 Clinical Trial.
METHODS: We compared a combination of nonprescription migraine medication (acetaminophen 500 mg, aspirin 500 mg, and caffeine 130 mg) with a prescription migraine product (50 mg sumatriptan) in a randomized, controlled clinical trial in which subjects treated …
METHODS: We compared a combination of nonprescription migraine medication (acetaminophen 500 mg, aspirin 500 mg, and caffei …
Efficacy of low dose combination analgesics: acetaminophen/codeine, aspirin/butalbital/caffeine/codeine, and placebo in oral surgery pain.
Desjardins PJ, Cooper SA, Finizio T. Desjardins PJ, et al. Anesth Prog. 1986 May-Jun;33(3):143-6. Anesth Prog. 1986. PMID: 3461726 Free PMC article. Clinical Trial.
The aspirin/butalbital/caffeine/codeine combination was numerically superior to acetaminophen/codeine for every measure of analgesic efficacy but the differences did not achieve statistical significance. ...The adverse effects occurred equally among the three …
The aspirin/butalbital/caffeine/codeine combination was numerically superior to acetaminophen/codeine for every measure …
Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain: three double-blind, randomized, placebo-controlled trials.
Lipton RB, Stewart WF, Ryan RE Jr, Saper J, Silberstein S, Sheftell F. Lipton RB, et al. Arch Neurol. 1998 Feb;55(2):210-7. doi: 10.1001/archneur.55.2.210. Arch Neurol. 1998. PMID: 9482363 Clinical Trial.
OBJECTIVE: To assess the effectiveness of the nonprescription combination of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain. DESIGN: Three double-blind, randomized, parallel-group, single-dose, placebo-controlled studies. ...INTERV …
OBJECTIVE: To assess the effectiveness of the nonprescription combination of acetaminophen, aspirin, and caffeine in al …
Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study.
Goldstein J, Silberstein SD, Saper JR, Ryan RE Jr, Lipton RB. Goldstein J, et al. Headache. 2006 Mar;46(3):444-53. doi: 10.1111/j.1526-4610.2006.00376.x. Headache. 2006. PMID: 16618262 Clinical Trial.
OBJECTIVE: Compare the effectiveness of a combination analgesic containing acetaminophen, aspirin, and caffeine to that of ibuprofen in the treatment of migraine. METHODS: Multicenter, double-blind, randomized, parallel-group, placebo-controlled, single-dose …
OBJECTIVE: Compare the effectiveness of a combination analgesic containing acetaminophen, aspirin, and caffeine to that …
Caffeine as an analgesic adjuvant.
Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A. Laska EM, et al. JAMA. 1984 Apr 6;251(13):1711-8. JAMA. 1984. PMID: 6366275 Clinical Trial.
In 21 of 26 studies, the relative potency estimates of an analgesic with caffeine to an analgesic without caffeine is greater than one. The pooled relative potency estimates in each of several major categories of combination analgesics are significantly greater than …
In 21 of 26 studies, the relative potency estimates of an analgesic with caffeine to an analgesic without caffeine is greater …
Analgesic effect of an aspirin-codeine-butalbital-caffeine combination and an acetaminophen-codeine combination in postoperative oral surgery pain.
Forbes JA, Jones KF, Smith WK, Gongloff CM. Forbes JA, et al. Pharmacotherapy. 1986 Sep-Oct;6(5):240-7. doi: 10.1002/j.1875-9114.1986.tb03483.x. Pharmacotherapy. 1986. PMID: 3540875 Clinical Trial.
The efficacy of an aspirin-caffeine-codeine-butalbital combination was compared to an acetaminophen-codeine combination and placebo in outpatients who had moderate or severe pain after the surgical removal of impacted third molars. ...Although the butalbital- …
The efficacy of an aspirin-caffeine-codeine-butalbital combination was compared to an acetaminophen-codeine combination …
Treatment of menstruation-associated migraine with the nonprescription combination of acetaminophen, aspirin, and caffeine: results from three randomized, placebo-controlled studies.
Silberstein SD, Armellino JJ, Hoffman HD, Battikha JP, Hamelsky SW, Stewart WF, Lipton RB. Silberstein SD, et al. Clin Ther. 1999 Mar;21(3):475-91. doi: 10.1016/S0149-2918(00)88303-4. Clin Ther. 1999. PMID: 10321417 Clinical Trial.
This retrospective study sought to examine the benefits of the nonprescription combination of acetaminophen, aspirin, and caffeine (AAC; Excedrin Migraine, Bristol-Myers Squibb Company, New York, New York) for the treatment of menstruation-associated migraine …
This retrospective study sought to examine the benefits of the nonprescription combination of acetaminophen, aspirin, and c …
Caffeine as an analgesic adjuvant in tension headache.
Migliardi JR, Armellino JJ, Friedman M, Gillings DB, Beaver WT. Migliardi JR, et al. Clin Pharmacol Ther. 1994 Nov;56(5):576-86. doi: 10.1038/clpt.1994.179. Clin Pharmacol Ther. 1994. PMID: 7955822 Clinical Trial.
In four studies, comprising 1900 patients, the caffeine-containing analgesic consisted of a combination of 500 mg acetaminophen, 500 mg aspirin, and 130 mg caffeine (APAP/ASA/CAF). In two studies, comprising 911 patients, the caffeine-containing …
In four studies, comprising 1900 patients, the caffeine-containing analgesic consisted of a combination of 500 mg acetaminophen …
Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized, placebo-controlled studies of the combination of acetaminophen, aspirin, and caffeine.
Goldstein J, Hoffman HD, Armellino JJ, Battikha JP, Hamelsky SW, Couch J, Blumenthal H, Lipton RB. Goldstein J, et al. Cephalalgia. 1999 Sep;19(7):684-91. doi: 10.1046/j.1468-2982.1999.019007684.x. Cephalalgia. 1999. PMID: 10524663 Clinical Trial.
OBJECTIVE: To examine the benefits of acetaminophen, aspirin, and caffeine (AAC) in the treatment of severe, disabling migraine attacks, in a population of migraine sufferers for whom over-the-counter (OTC) medications are appropriate. ...
OBJECTIVE: To examine the benefits of acetaminophen, aspirin, and caffeine (AAC) in the treatment of severe, disabling …
The use of ibuprofen plus caffeine to treat tension-type headache.
Diamond S, Freitag FG. Diamond S, et al. Curr Pain Headache Rep. 2001 Oct;5(5):472-8. doi: 10.1007/s11916-001-0060-8. Curr Pain Headache Rep. 2001. PMID: 11560814 Clinical Trial.
Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache. Studies of combination agents of aspirin with caffeine or acetaminophen with caffeine have also demonstrated ef …
Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache. …
41 results