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Bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a fixed-combination syrup versus an oral reference product.
Janin A, Monnet J. Janin A, et al. J Int Med Res. 2014 Apr;42(2):347-59. doi: 10.1177/0300060513503762. Epub 2014 Feb 19. J Int Med Res. 2014. PMID: 24553480 Free article. Clinical Trial.
OBJECTIVES: The primary objective of this study was to compare the bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a new oral syrup with an established oral reference product. ...Blood samples were taken regularly postdose and a …
OBJECTIVES: The primary objective of this study was to compare the bioavailability of paracetamol, phenylephrine hydrochloride …
An open-label, randomized, four-treatment crossover study evaluating the effects of salt form, acetaminophen, and food on the pharmacokinetics of phenylephrine.
Gelotte CK. Gelotte CK. Regul Toxicol Pharmacol. 2018 Jun;95:333-338. doi: 10.1016/j.yrtph.2018.04.008. Epub 2018 Apr 7. Regul Toxicol Pharmacol. 2018. PMID: 29635061 Free article. Clinical Trial.
Test treatments were 25 mg phenylephrine tannate (equivalent to 10 mg phenylephrine HCl) combined with 200 mg guaifenesin, fasted; 10 mg phenylephrine HCl combined with 650 mg acetaminophen, fasted; and 10 mg phenylephrine HCl, fed. ...Th …
Test treatments were 25 mg phenylephrine tannate (equivalent to 10 mg phenylephrine HCl) combined with 200 mg guaifenesin …
Robust Chromatographic Methods for the Analysis of Two Quaternary Mixtures Containing Paracetamol, Codeine, Guaifenesin and Pseudoephedrine or Phenylephrine in their Dosage Forms.
El-Kimary EI, Khamis EF, Belal SF, Abdel Moneim MM. El-Kimary EI, et al. J Chromatogr Sci. 2019 Oct 17;57(9):828-837. doi: 10.1093/chromsci/bmz057. J Chromatogr Sci. 2019. PMID: 31504290
Two simple validated and highly selective methods for analysis of paracetamol, codeine, guaifenesin and pseudoephedrine or phenylephrine quaternary mixtures were developed. ...
Two simple validated and highly selective methods for analysis of paracetamol, codeine, guaifenesin and pseudoephedrine or …
Corrigendum.
[No authors listed] [No authors listed] J Int Med Res. 2014 Aug;42(4):1060-1. doi: 10.1177/0300060514533283. Epub 2014 Jun 5. J Int Med Res. 2014. PMID: 24903555 Free article.
The authors would like to bring attention to the error published in 'Bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a fixed-combination syrup versus an oral reference product' 'Annick Janin and Joelle Monnet' Journal of Interna …
The authors would like to bring attention to the error published in 'Bioavailability of paracetamol, phenylephrine hydrochlori …
Trends in US Pediatric Unintentional Nonprescription Cold and Cough, Analgesic and Antipyretic Drug Exposure Cases amid the COVID-19 Pandemic.
Karami S, Ventura CAI, Pinnow E, Green J, Asonye A, Ibrahim IT, McCulley L, Dal Pan GJ, Zhou EH. Karami S, et al. Clin Drug Investig. 2025 Jul;45(7):401-416. doi: 10.1007/s40261-025-01444-9. Epub 2025 May 28. Clin Drug Investig. 2025. PMID: 40434620 Free PMC article.
METHODS: We included dextromethorphan, guaifenesin, phenylephrine, and pseudoephedrine CC drugs, and acetaminophen, naproxen, ibuprofen, and acetylsalicylic acid AA drugs; statins served as a control. ...
METHODS: We included dextromethorphan, guaifenesin, phenylephrine, and pseudoephedrine CC drugs, and acetaminophen, nap …
Enzyme Models-From Catalysis to Prodrugs.
Breijyeh Z, Karaman R. Breijyeh Z, et al. Molecules. 2021 May 28;26(11):3248. doi: 10.3390/molecules26113248. Molecules. 2021. PMID: 34071328 Free PMC article. Review.
A large number of prodrugs have been designed and developed to improve the effectiveness and pharmacokinetics of commonly used drugs, such as anti-Parkinson (dopamine), antiviral (acyclovir), antimalarial (atovaquone), anticancer (azanucleosides), antifibrinolytic (tranexamic aci …
A large number of prodrugs have been designed and developed to improve the effectiveness and pharmacokinetics of commonly used drugs, such a …
Rapid screening and multicomponent quantifications of active components of oral syrup over-the-counter medications by Raman and UV-visible spectroscopy and multivariate regression analysis.
Fakayode SO, Bolton B, Dassow B, Galvez K, Chohan H. Fakayode SO, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 15;305:123447. doi: 10.1016/j.saa.2023.123447. Epub 2023 Sep 21. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 37742594
PLS regressions of UV-visible absorption spectra were used for multicomponent quantifications of the active component (acetaminophen, guaifenesin, dextromethorphan HBr, and phenylephrine HCl) concentrations of OTMCs in flavored (sugar or sugar-free) oral syru …
PLS regressions of UV-visible absorption spectra were used for multicomponent quantifications of the active component (acetaminophen, …
Facile Electrochemical Sensor for Sensitive and Selective Determination of Guaifenesin, Phenylephrine and Paracetamol on Electrochemically Pretreated Pencil Graphite Electrode.
Buleandră M, Pătrașcu AA, Popa DE, David IG, Badea IA, Ciucu AA. Buleandră M, et al. Micromachines (Basel). 2022 Jul 29;13(8):1213. doi: 10.3390/mi13081213. Micromachines (Basel). 2022. PMID: 36014134 Free PMC article.
Guaifenesin (GFS), phenylephrine (PHE) and paracetamol (PAR), drugs used in combination for the relief of cold and flu symptoms, were determined at electrochemically pretreated pencil graphite electrode. ...
Guaifenesin (GFS), phenylephrine (PHE) and paracetamol (PAR), drugs used in combination for the relief of cold and flu …
Bilateral simultaneous acute angle closure glaucoma triggered by an over-the-counter cold and influenza medication.
Chean CS, Ali AIAH, Malick H. Chean CS, et al. BMJ Case Rep. 2024 Aug 30;17(8):e260950. doi: 10.1136/bcr-2024-260950. BMJ Case Rep. 2024. PMID: 39214584 Free PMC article.
A woman in her mid-60s who is a high hypermetrope presented with bilateral eye pain and headache approximately 1 hour after taking a single dose of a widely available decongestant containing paracetamol, guaifenesin and phenylephrine hydrochloride for coryzal …
A woman in her mid-60s who is a high hypermetrope presented with bilateral eye pain and headache approximately 1 hour after taking a single …
Development and validation of a generic RP-HPLC PDA method for the simultaneous separation and quantification of active ingredients in cold and cough medicines.
Dongala T, Katari NK, Palakurthi AK, Jonnalagadda SB. Dongala T, et al. Biomed Chromatogr. 2019 Nov;33(11):e4641. doi: 10.1002/bmc.4641. Epub 2019 Aug 8. Biomed Chromatogr. 2019. PMID: 31265736
A novel generic reverse phase high performance liquid chromatography (RP-HPLC) method is developed and validated for simultaneous determination of seven pharmaceutically active ingredients, namely, acetaminophen, dextromethorphan, doxylamine, phenylephrine, guaif …
A novel generic reverse phase high performance liquid chromatography (RP-HPLC) method is developed and validated for simultaneous determinat …
22 results