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132 results

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Page 1
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.
Jones J, Correll DJ, Lechner SM, Jazic I, Miao X, Shaw D, Simard C, Osteen JD, Hare B, Beaton A, Bertoch T, Buvanendran A, Habib AS, Pizzi LJ, Pollak RA, Weiner SG, Bozic C, Negulescu P, White PF; VX21-548-101 and VX21-548-102 Trial Groups. Jones J, et al. N Engl J Med. 2023 Aug 3;389(5):393-405. doi: 10.1056/NEJMoa2209870. N Engl J Med. 2023. PMID: 37530822 Clinical Trial.
In the abdominoplasty trial, participants were randomly assigned in a 1:1:1:1 ratio to receive one of the following over a 48-hour period: a 100-mg oral loading dose of VX-548, followed by a 50-mg maintenance dose every 12 hours (the high-dose group); a 60-mg loading dose of VX-5 …
In the abdominoplasty trial, participants were randomly assigned in a 1:1:1:1 ratio to receive one of the following over a 48-hour period: a …
Suzetrigine, a Nonopioid Na V 1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials.
Bertoch T, D'Aunno D, McCoun J, Solanki D, Taber L, Urban J, Oswald J, Swisher MW, Tian S, Miao X, Correll DJ, Negulescu P, Bozic C, Weiner SG. Bertoch T, et al. Anesthesiology. 2025 Jun 1;142(6):1085-1099. doi: 10.1097/ALN.0000000000005460. Epub 2025 Mar 21. Anesthesiology. 2025. PMID: 40117446 Free PMC article. Clinical Trial.
Key secondary endpoints were SPID48 versus hydrocodone bitartrate/acetaminophen and time to 2-point or greater reduction in numeric pain rating scale from baseline versus placebo. ...Pain reduction with suzetrigine was similar to that with hydrocodone bitartr …
Key secondary endpoints were SPID48 versus hydrocodone bitartrate/acetaminophen and time to 2-point or greater reduction in nu …
Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.
Krebs EE, Gravely A, Nugent S, Jensen AC, DeRonne B, Goldsmith ES, Kroenke K, Bair MJ, Noorbaloochi S. Krebs EE, et al. JAMA. 2018 Mar 6;319(9):872-882. doi: 10.1001/jama.2018.0899. JAMA. 2018. PMID: 29509867 Free PMC article. Clinical Trial.
In the opioid group, the first step was immediate-release morphine, oxycodone, or hydrocodone/acetaminophen. For the nonopioid group, the first step was acetaminophen (paracetamol) or a nonsteroidal anti-inflammatory drug. ...
In the opioid group, the first step was immediate-release morphine, oxycodone, or hydrocodone/acetaminophen. For the nonopioid …
Nonopioid vs opioid analgesics after impacted third-molar extractions: The Opioid Analgesic Reduction Study randomized clinical trial.
Feldman CA, Fredericks-Younger J, Desjardins PJ, Malmstrom H, Miloro M, Warburton G, Ward BB, Ziccardi VB, Greenberg P, Andrews T, Matheson PB, Benoliel R, Fine DH, Lu SE. Feldman CA, et al. J Am Dent Assoc. 2025 Feb;156(2):110-123.e9. doi: 10.1016/j.adaj.2024.10.014. Epub 2025 Jan 4. J Am Dent Assoc. 2025. PMID: 39755971 Free article. Clinical Trial.
Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioid) or 400 mg of ibuprofen and 500 mg of acetaminophen (nonopioid). ...Participants not taking opioids had higher overall satisfaction at the postoperative visit (85 …
Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioid) or 400 mg of ibuprofen and 5 …
Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge.
Chang AK, Bijur PE, Munjal KG, John Gallagher E. Chang AK, et al. Acad Emerg Med. 2014 Mar;21(3):227-35. doi: 10.1111/acem.12331. Acad Emerg Med. 2014. PMID: 24628747 Free article. Clinical Trial.
OBJECTIVES: The objective was to test the hypothesis that hydrocodone/acetaminophen (Vicodin [5/500]) provides more efficacious analgesia than codeine/acetaminophen (Tylenol #3 [30/300]) in patients discharged from the emergency department (ED). ...Similarly, …
OBJECTIVES: The objective was to test the hypothesis that hydrocodone/acetaminophen (Vicodin [5/500]) provides more efficaciou …
Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial.
Rodriguez RF, Castillo JM, Castillo MP, Montoya O, Daza P, Rodríguez MF, Restrepo JM, León ME, Angel AM. Rodriguez RF, et al. Clin J Pain. 2008 Jan;24(1):1-4. doi: 10.1097/AJP.0b013e318156ca4d. Clin J Pain. 2008. PMID: 18180628 Clinical Trial.
Sixty-two patients received hydrocodone and 56 patients received tramadol. RESULTS: Hydrocodone/acetaminophen was effective in relieving pain in 56.5% of the patients at the starting dose of 25 mg/2500 mg/d. ...CONCLUSIONS: There was no superior analgesic eff …
Sixty-two patients received hydrocodone and 56 patients received tramadol. RESULTS: Hydrocodone/acetaminophen was effec …
Clinical efficacy of hydrocodone-acetaminophen and tramadol for control of postoperative pain in dogs following tibial plateau leveling osteotomy.
Benitez ME, Roush JK, McMurphy R, KuKanich B, Legallet C. Benitez ME, et al. Am J Vet Res. 2015 Sep;76(9):755-62. doi: 10.2460/ajvr.76.9.755. Am J Vet Res. 2015. PMID: 26309103 Free article. Clinical Trial.
OBJECTIVE: To evaluate clinical efficacy of hydrocodone-acetaminophen and tramadol for treatment of postoperative pain in dogs undergoing tibial plateau leveling osteotomy (TPLO). ...Each patient was randomly assigned to receive either tramadol hydrochloride (5 to 7 …
OBJECTIVE: To evaluate clinical efficacy of hydrocodone-acetaminophen and tramadol for treatment of postoperative pain in dogs …
Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial.
Turturro MA, Paris PM, Larkin GL. Turturro MA, et al. Ann Emerg Med. 1998 Aug;32(2):139-43. doi: 10.1016/s0196-0644(98)70127-1. Ann Emerg Med. 1998. PMID: 9701294 Clinical Trial.
Thirty-three patients received tramadol (100 mg), and 35 patients received hydrocodone-acetaminophen (5 mg hydrocodone with 500 mg acetaminophen). The drugs were prepared in identical-appearing capsules. ...RESULTS: Mean pain scores did not differ at b …
Thirty-three patients received tramadol (100 mg), and 35 patients received hydrocodone-acetaminophen (5 mg hydrocodone …
Evaluation of Hydrocodone/Acetaminophen for Pediatric Laceration Repair: A Randomized Trial.
Chumpitazi CE, Caviness AC, Grawe GH, Camp EA, Shah MI. Chumpitazi CE, et al. Plast Reconstr Surg. 2020 Jan;145(1):126e-134e. doi: 10.1097/PRS.0000000000006383. Plast Reconstr Surg. 2020. PMID: 31881621 Clinical Trial.
The purpose of this study was to measure the effect of hydrocodone/acetaminophen elixir in reducing both pain and anxiety in children undergoing sutured laceration repair in the emergency department. ...RESULTS: Eighty-five children were randomized, 43 to the hyd …
The purpose of this study was to measure the effect of hydrocodone/acetaminophen elixir in reducing both pain and anxiety in c …
132 results