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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1992 1
1994 4
1995 1
1996 4
1997 8
1998 14
1999 5
2000 13
2001 8
2002 18
2003 26
2004 27
2005 41
2006 37
2007 37
2008 29
2009 38
2010 32
2011 58
2012 56
2013 50
2014 53
2015 61
2016 50
2017 71
2018 79
2019 68
2020 88
2021 72
2022 70
2023 92
2024 70
2025 63
2026 41

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1,234 results

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Page 1
Pharmaceutical treatment of osteoarthritis.
Richard MJ, Driban JB, McAlindon TE. Richard MJ, et al. Osteoarthritis Cartilage. 2023 Apr;31(4):458-466. doi: 10.1016/j.joca.2022.11.005. Epub 2022 Nov 19. Osteoarthritis Cartilage. 2023. PMID: 36414224 Free article. Review.
METHOD: A narrative review was drafted to describe treatment guidelines, mechanism of action, pharmacokinetics, and toxicity for nine classes of pharmaceuticals: 1) oral nonsteroidal anti-inflammatory drugs (NSAIDs), 2) topical NSAIDs, 3) COX-2 inhibitors, 4) duloxetine, 5) intra …
METHOD: A narrative review was drafted to describe treatment guidelines, mechanism of action, pharmacokinetics, and toxicity for nine classe …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
The results were then reviewed with identification of commonly used drugs and drug categories: nonsteroidal anti-inflammatories (NSAIDs), acetaminophen, corticosteroids, gabapentin and pregabalin, antispastic and antispasmodic muscle relaxants, tricyclic antidepressants (T …
The results were then reviewed with identification of commonly used drugs and drug categories: nonsteroidal anti-inflammatories (NSAIDs), …
Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review.
Wick EC, Grant MC, Wu CL. Wick EC, et al. JAMA Surg. 2017 Jul 1;152(7):691-697. doi: 10.1001/jamasurg.2017.0898. JAMA Surg. 2017. PMID: 28564673 Review.
The goal of this article was to outline important components of opioid-sparing analgesic regimens. OBSERVATIONS: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory agents, gabapentinoids, tramadol, lidocaine, and/or the N-methyl-d-aspartate class of g …
The goal of this article was to outline important components of opioid-sparing analgesic regimens. OBSERVATIONS: Regional analgesia, acet …
Tramadol/paracetamol.
McClellan K, Scott LJ. McClellan K, et al. Drugs. 2003;63(11):1079-86; discussion 1087-8. doi: 10.2165/00003495-200363110-00007. Drugs. 2003. PMID: 12749738 Review.
Two tramadol/paracetamol 37.5/325 mg tablets provided greater relief of dental pain over an 8-hour period than either agent alone, with a faster onset of action than tramadol alone and a longer duration of action than either agent as monotherapy. In patients …
Two tramadol/paracetamol 37.5/325 mg tablets provided greater relief of dental pain over an 8-hour period than either agent al …
Opioids for cancer pain - an overview of Cochrane reviews.
Wiffen PJ, Wee B, Derry S, Bell RF, Moore RA. Wiffen PJ, et al. Cochrane Database Syst Rev. 2017 Jul 6;7(7):CD012592. doi: 10.1002/14651858.CD012592.pub2. Cochrane Database Syst Rev. 2017. PMID: 28683172 Free PMC article.
The most commonly-used opioid drugs are buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, tramadol, and tapentadol. OBJECTIVES: To provide an overview of the analgesic efficacy of opioids in cancer pain, and to report on adverse …
The most commonly-used opioid drugs are buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, tra …
[Neuropathic Pain].
Igari H, Ushida T. Igari H, et al. Brain Nerve. 2023 May;75(5):567-571. doi: 10.11477/mf.1416202380. Brain Nerve. 2023. PMID: 37194533 Japanese.
Many diseases are associated with "neuropathic pain", which is not usually manageable with common analgesics, such as NSAIDs and acetaminophen. Calcium ion channel alpha2delta ligands, serotonin-noradrenaline reuptake inhibitors, and tricyclic antidepressants have been use …
Many diseases are associated with "neuropathic pain", which is not usually manageable with common analgesics, such as NSAIDs and acetamin …
Tramadol (with or without acetaminophen) efficacy and harm: Systematic review and meta-analysis.
Otte JA, Chu G, Heran B, Bassett K. Otte JA, et al. Can Fam Physician. 2025 Sep;71(9):574-581. doi: 10.46747/cfp.7109574. Can Fam Physician. 2025. PMID: 40940161 Free PMC article.
OBJECTIVE: To evaluate the efficacy and safety of tramadol (with or without acetaminophen) in adult pain management compared with nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen alone. ...Compared with NSAIDs, tramadol with or …
OBJECTIVE: To evaluate the efficacy and safety of tramadol (with or without acetaminophen) in adult pain management compared w …
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews.
Cashin AG, Wand BM, O'Connell NE, Lee H, Rizzo RR, Bagg MK, O'Hagan E, Maher CG, Furlan AD, van Tulder MW, McAuley JH. Cashin AG, et al. Cochrane Database Syst Rev. 2023 Apr 4;4(4):CD013815. doi: 10.1002/14651858.CD013815.pub2. Cochrane Database Syst Rev. 2023. PMID: 37014979 Free PMC article. Review.
The reviews reported data on six medicines or medicine classes: paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, benzodiazepines, opioids, and antidepressants. ...For acute LBP, we found moderate-certainty evidence that NSAIDs and muscle relax …
The reviews reported data on six medicines or medicine classes: paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), muscle r …
Tramadol and acetaminophen tablets for dental pain.
Medve RA, Wang J, Karim R. Medve RA, et al. Anesth Prog. 2001 Summer;48(3):79-81. Anesth Prog. 2001. PMID: 11724223 Free PMC article. Clinical Trial.
The purpose of this work was to compare the efficacy and time to analgesia of a new tramadol/acetaminophen combination tablet to those of tramadol or acetaminophen (APAP) alone. ...A new combination analgesic, tramadol/APAP, is superior to tr …
The purpose of this work was to compare the efficacy and time to analgesia of a new tramadol/acetaminophen combination tablet …
Tramadol and acetaminophen combination for chronic non-cancer pain.
Farquhar-Smith P, Gubbay A. Farquhar-Smith P, et al. Expert Opin Pharmacother. 2013 Nov;14(16):2297-304. doi: 10.1517/14656566.2013.839985. Epub 2013 Sep 26. Expert Opin Pharmacother. 2013. PMID: 24067074 Review.
AREAS COVERED: This review discusses use of tramadol in chronic non-cancer pain and the pharmacokinetics/pharmacodynamics of tramadol and acetaminophen and when combined. ...EXPERT OPINION: Combination therapy with tramadol and acetaminophen red …
AREAS COVERED: This review discusses use of tramadol in chronic non-cancer pain and the pharmacokinetics/pharmacodynamics of trama …
1,234 results