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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1968 4
1969 2
1970 3
1971 2
1973 4
1974 4
1975 4
1976 3
1977 2
1978 1
1979 3
1980 6
1981 2
1982 3
1983 4
1984 6
1985 9
1986 6
1987 4
1988 9
1989 11
1990 6
1991 10
1992 9
1993 5
1994 15
1995 16
1996 18
1997 17
1998 16
1999 19
2000 17
2001 17
2002 35
2003 40
2004 31
2005 35
2006 38
2007 43
2008 46
2009 42
2010 52
2011 52
2012 63
2013 66
2014 62
2015 46
2016 55
2017 48
2018 52
2019 51
2020 47
2021 41
2022 32
2023 40
2024 24
2025 30
2026 1

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1,188 results

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Page 1
N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.
Fang YQ, Ding H, Li T, Zhao XJ, Luo D, Liu Y, Li Y. Fang YQ, et al. J Ovarian Res. 2024 Oct 16;17(1):205. doi: 10.1186/s13048-024-01528-8. J Ovarian Res. 2024. PMID: 39415242 Free PMC article. Clinical Trial.
Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxidant and insulin sensitizer that shows promise as a therapeutic for PCOS. ...
Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxidant and insuli …
Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis.
Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B, Dupas JL; AAH-NAC Study Group. Nguyen-Khac E, et al. N Engl J Med. 2011 Nov 10;365(19):1781-9. doi: 10.1056/NEJMoa1101214. N Engl J Med. 2011. PMID: 22070475 Free article. Clinical Trial.
We investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival. METHODS: We randomly assigned 174 patients to receive prednisolone plus N-acetylcysteine (85 patients) or only prednisolone (89 patients). ...Secondary out …
We investigated whether combination therapy with glucocorticoids plus N-acetylcysteine would improve survival. METHODS: We randomly a …
A non-inferiority randomised controlled trial of a shorter acetylcysteine regimen for paracetamol overdose - the SARPO trial.
Isbister G, Chiew A, Buckley N, Harris K, Berling I, Downes M, Page C, Isoardi K. Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Epub 2025 May 23. J Hepatol. 2025. PMID: 40414507 Free article. Clinical Trial.
BACKGROUND & AIMS: Paracetamol is a commonly overdosed medication worldwide. Early acetylcysteine treatment can prevent hepatotoxicity. Multiple intravenous acetylcysteine regimens exist; the commonest recommending 300 mg/kg over 20 h. ...METHODS: In a multicent …
BACKGROUND & AIMS: Paracetamol is a commonly overdosed medication worldwide. Early acetylcysteine treatment can prevent hepatotox …
Efficacy and safety of combined nebulization of unfractionated heparin, acetylcysteine, budesonide and ipratropium bromide in hospitalised patients with COVID-19 pneumonia: a randomized controlled clinical trial.
Gong J, Nie N, Jiang M, Yang X, Wang Q, Deng J, Kang J, Li X, Zhang L, Zhang Y, Luo N, Du X, Wang L, Zhou W, Cao H, Li K, Cao G, Li L. Gong J, et al. BMC Pulm Med. 2025 Jul 22;25(1):346. doi: 10.1186/s12890-025-03824-5. BMC Pulm Med. 2025. PMID: 40696325 Free PMC article. Clinical Trial.
This study aimed to evaluate the efficacy and safety of nebulized unfractionated heparin, acetylcysteine, budesonide, and ipratropium bromide (HABIT) in hospitalized patients with COVID-19 pneumonia. ...The HABIT protocol included daily quadruple nebulization for seven day …
This study aimed to evaluate the efficacy and safety of nebulized unfractionated heparin, acetylcysteine, budesonide, and ipratropium …
Evaluation the efficacy and safety of N-acetylcysteine inhalation spray in controlling the symptoms of patients with COVID-19: An open-label randomized controlled clinical trial.
Panahi Y, Ghanei M, Rahimi M, Samim A, Vahedian-Azimi A, Atkin SL, Sahebkar A. Panahi Y, et al. J Med Virol. 2023 Jan;95(1):e28393. doi: 10.1002/jmv.28393. J Med Virol. 2023. PMID: 36495185 Free PMC article. Clinical Trial.
The aim of this study was to evaluate the effect and safety of N-acetylcysteine (NAC) inhalation spray in the treatment of patients with coronavirus disease 2019 (COVID-19). ...
The aim of this study was to evaluate the effect and safety of N-acetylcysteine (NAC) inhalation spray in the treatment of patients w …
Effects of N-Acetylcysteine combined with Ambroxol Hydrochloride on clinical symptoms, CRP, and PCT in children with pneumonia.
Xue A, Zhang H, Song S, Yu X. Xue A, et al. Clinics (Sao Paulo). 2024 Aug 28;79:100476. doi: 10.1016/j.clinsp.2024.100476. eCollection 2024. Clinics (Sao Paulo). 2024. PMID: 39208656 Free PMC article. Clinical Trial.
OBJECTIVE: This study investigated the effects of N-Acetylcysteine (NAC) combined with Ambroxol Hydrochloride (AH) on clinical symptoms, C-Reactive Protein (CRP), and Procalcitonin (PCT) levels in children with pneumonia. ...
OBJECTIVE: This study investigated the effects of N-Acetylcysteine (NAC) combined with Ambroxol Hydrochloride (AH) on clinical sympto …
Efficacy of N-acetylcysteine and motivational enhancement therapy for nicotine addiction: A randomized clinical trial.
Nasrun MW, Ginting TT, Siste K, Pandelaki J, Kekalih A, Louisa M, Susanto AD, Utami DS, Tarigan IN, Trishna AR, Halim K. Nasrun MW, et al. Narra J. 2025 Apr;5(1):e2178. doi: 10.52225/narra.v5i1.2178. Epub 2025 Mar 24. Narra J. 2025. PMID: 40352229 Free PMC article. Clinical Trial.
N-acetylcysteine (NAC) is known to enhance neuroplasticity and help reduce smoking addiction by modulating brain metabolites. ...
N-acetylcysteine (NAC) is known to enhance neuroplasticity and help reduce smoking addiction by modulating brain metabolites. ...
Evaluation of the efficacy of N-acetylcysteine and bromhexine compared with standard care in preventing hospitalization of outpatients with COVID-19: a double blind randomized clinical trial.
Eslami Ghayour A, Nazari S, Keramat F, Shahbazi F, Eslami-Ghayour A. Eslami Ghayour A, et al. Rev Clin Esp (Barc). 2024 Feb;224(2):86-95. doi: 10.1016/j.rceng.2023.12.011. Epub 2024 Jan 11. Rev Clin Esp (Barc). 2024. PMID: 38215974 Clinical Trial.
RESULTS: The study found that both N-acetylcysteine and Bromhexine can effectively reduce hospitalization rates and mortality and shorten the duration of hospitalization. The third visit of patients who received N-acetylcysteine showed an increase of 1.33% in oxygen …
RESULTS: The study found that both N-acetylcysteine and Bromhexine can effectively reduce hospitalization rates and mortality and sho …
Safety and Pharmacokinetics of a Combined Antioxidant Therapy against Myocardial Reperfusion Injury: A Phase 1 Randomized Clinical Trial in Healthy Humans.
Gajardo Cortez AIJ, Lillo-Moya J, San-Martín-Martinez D, Pozo-Martinez J, Morales P, Prieto JC, Aguayo R, Puentes Á, Ramos C, Silva S, Catalán M, Ramos K, Olea-Azar C, Rodrigo R. Gajardo Cortez AIJ, et al. Clin Pharmacol Drug Dev. 2024 Sep;13(9):1051-1060. doi: 10.1002/cpdd.1443. Epub 2024 Jul 8. Clin Pharmacol Drug Dev. 2024. PMID: 38973337 Clinical Trial.
We previously reduced MRI in rats through a combined antioxidant therapy (CAT) of ascorbic acid, N-acetylcysteine, and deferoxamine. This study determines the safety and pharmacokinetics of CAT in a Phase I clinical trial. ...Blood samples were collected at specific times …
We previously reduced MRI in rats through a combined antioxidant therapy (CAT) of ascorbic acid, N-acetylcysteine, and deferoxamine. …
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.
Heard K, Rumack BH, Green JL, Bucher-Bartelson B, Heard S, Bronstein AC, Dart RC. Heard K, et al. Clin Toxicol (Phila). 2014 Jun;52(5):512-8. doi: 10.3109/15563650.2014.902955. Epub 2014 Apr 8. Clin Toxicol (Phila). 2014. PMID: 24708414 Clinical Trial.
INTRODUCTION: Acetylcysteine prevents hepatic injury when administered soon after acetaminophen overdose. ...This protocol delivers a higher dose of acetylcysteine which may be useful in selected cases involving very large overdoses....
INTRODUCTION: Acetylcysteine prevents hepatic injury when administered soon after acetaminophen overdose. ...This protocol delivers a …
1,188 results