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1990 2
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776 results

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Page 1
Managing acne vulgaris: an update.
Santer M, Burden-Teh E, Ravenscroft J. Santer M, et al. Drug Ther Bull. 2023 Dec 27;62(1):6-10. doi: 10.1136/dtb.2023.000051. Drug Ther Bull. 2023. PMID: 38154809 Free PMC article. Review.
Guidelines unanimously advise topical treatments as first-line, although differ in recommending either topical benzoyl peroxide or topical retinoid (mainly adapalene) alone or in combination. Guidance published by the National Institute for Health and Care Excellence advis …
Guidelines unanimously advise topical treatments as first-line, although differ in recommending either topical benzoyl peroxide or topical r …
Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells.
Colucci M, Zumerle S, Bressan S, Gianfanti F, Troiani M, Valdata A, D'Ambrosio M, Pasquini E, Varesi A, Cogo F, Mosole S, Dongilli C, Desbats MA, Contu L, Revankdar A, Chen J, Kalathur M, Perciato ML, Basilotta R, Endre L, Schauer S, Othman A, Guccini I, Saponaro M, Maraccani L, Bancaro N, Lai P, Liu L, Pernigoni N, Mele F, Merler S, Trotman LC, Guarda G, Calì B, Montopoli M, Alimonti A. Colucci M, et al. Cancer Cell. 2024 Apr 8;42(4):646-661.e9. doi: 10.1016/j.ccell.2024.02.004. Epub 2024 Feb 29. Cancer Cell. 2024. PMID: 38428412 Free PMC article.
Here, we identify the retinoic-acid-receptor (RAR) agonist adapalene as an effective pro-senescence compound in prostate cancer (PCa). Reactivation of RARs triggers a robust senescence response and a tumor-suppressive SASP. In preclinical mouse models of PCa, the combinati …
Here, we identify the retinoic-acid-receptor (RAR) agonist adapalene as an effective pro-senescence compound in prostate cancer (PCa) …
Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations.
Milosheska D, Roškar R. Milosheska D, et al. Adv Ther. 2022 Dec;39(12):5351-5375. doi: 10.1007/s12325-022-02319-7. Epub 2022 Oct 11. Adv Ther. 2022. PMID: 36220974 Free PMC article. Review.
Of the other retinoids contained in medicines, tazarotene and adapalene have clinically evaluated antiaging effects compared to tretinoin and may be considered as potential alternatives for antiaging treatments. ...
Of the other retinoids contained in medicines, tazarotene and adapalene have clinically evaluated antiaging effects compared to treti …
Adapalene.
[No authors listed] [No authors listed] 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000483 Free Books & Documents. Review.
Topical adapalene has not been studied during breastfeeding. Because it is poorly absorbed after topical application, and blood levels are less than 0.25 mcg/L with long-term use, it is probably a low risk to the nursing infant.[1] Absorption should be minimized by applyin …
Topical adapalene has not been studied during breastfeeding. Because it is poorly absorbed after topical application, and blood level …
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
Liu H, Yu H, Xia J, Liu L, Liu GJ, Sang H, Peinemann F. Liu H, et al. Cochrane Database Syst Rev. 2020 May 1;5(5):CD011368. doi: 10.1002/14651858.CD011368.pub2. Cochrane Database Syst Rev. 2020. PMID: 32356369 Free PMC article.
There may be little or no difference in PGA when comparing azelaic acid to clindamycin (RR 1.13, 95% CI 0.92 to 1.38; 1 study, 229 participants; low-quality evidence), but we are uncertain whether there is a difference between azelaic acid and adapalene (1 study, 55 partic …
There may be little or no difference in PGA when comparing azelaic acid to clindamycin (RR 1.13, 95% CI 0.92 to 1.38; 1 study, 229 participa …
Ceramide-Containing Adjunctive Skin Care for Skin Barrier Restoration During Acne Vulgaris Treatment.
Draelos ZD, Baalbaki N, Colon G, Dreno B. Draelos ZD, et al. J Drugs Dermatol. 2023 Jun 1;22(6):554-558. doi: 10.36849/JDD.7142. J Drugs Dermatol. 2023. PMID: 37276158 Clinical Trial.
Barrier damage caused by facial acne vulgaris can be magnified by topical medication, such as adapalene (0.3%) and benzoyl peroxide (2.5%)(A/BPO), which utilizes a retinoid to normalize follicular keratinization and BPO to decrease the C. acnes population. ...
Barrier damage caused by facial acne vulgaris can be magnified by topical medication, such as adapalene (0.3%) and benzoyl peroxide ( …
Spotlight on adapalene.
Piérard GE, Piérard-Franchimont C, Paquet P, Quatresooz P. Piérard GE, et al. Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1565-75. doi: 10.1517/17425250903386269. Expert Opin Drug Metab Toxicol. 2009. PMID: 19929446
In acne, adapalene is expected to reduce comedogenesis, expel mature comedones and exert some anti-inflammatory effects. ...Clinical experience has established that adapalene represents a valuable addition to the other current treatments for acne....
In acne, adapalene is expected to reduce comedogenesis, expel mature comedones and exert some anti-inflammatory effects. ...Clinical …
Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug.
Stein Gold L, Baldwin H, Kircik LH, Weiss JS, Pariser DM, Callender V, Lain E, Gold M, Beer K, Draelos Z, Sadick N, Pillai R, Bhatt V, Tanghetti EA. Stein Gold L, et al. Am J Clin Dermatol. 2022 Jan;23(1):93-104. doi: 10.1007/s40257-021-00650-3. Epub 2021 Oct 21. Am J Clin Dermatol. 2022. PMID: 34674160 Free PMC article. Clinical Trial.
OBJECTIVES: We aimed to evaluate the efficacy and safety of triple-combination, fixed-dose topical clindamycin phosphate 1.2%/benzoyl peroxide (BPO) 3.1%/adapalene 0.15% (IDP-126) gel for the treatment of acne. METHODS: In a phase II, double-blind, multicenter, randomized, …
OBJECTIVES: We aimed to evaluate the efficacy and safety of triple-combination, fixed-dose topical clindamycin phosphate 1.2%/benzoyl peroxi …
Efficacy of topical treatments for mild-to-moderate acne: A systematic review and meta-analysis of randomized control trials.
Kakpovbia EE, Young T, Milam EC, Qian Y, Yassin S, Nicholson J, Hu J, Troxel AB, Nagler AR. Kakpovbia EE, et al. J Eur Acad Dermatol Venereol. 2025 Apr;39(4):775-784. doi: 10.1111/jdv.20154. Epub 2024 Jun 29. J Eur Acad Dermatol Venereol. 2025. PMID: 38943431
Thirty-five randomized clinical trials with 33,472 participants comparing nine different topical agents were included. Adapalene-benzoyl peroxide (BPO), clindamycin-BPO and clindamycin-tretinoin demonstrated the greatest reduction in non-inflammatory (ratio of means [RoM] …
Thirty-five randomized clinical trials with 33,472 participants comparing nine different topical agents were included. Adapalene-benz …
776 results