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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1931 1
1934 1
1935 2
1938 1
1939 1
1942 2
1943 1
1945 5
1946 44
1947 37
1948 51
1949 35
1950 61
1951 96
1952 112
1953 166
1954 197
1955 165
1956 204
1957 226
1958 198
1959 233
1960 226
1961 316
1962 427
1963 845
1964 1319
1965 1300
1966 1489
1967 1830
1968 2106
1969 2447
1970 2653
1971 3583
1972 4395
1973 4248
1974 4576
1975 4594
1976 4296
1977 4383
1978 3719
1979 3749
1980 3910
1981 3764
1982 3880
1983 3893
1984 4319
1985 4669
1986 4562
1987 4390
1988 4597
1989 4973
1990 5261
1991 5418
1992 5513
1993 5790
1994 5980
1995 5844
1996 5836
1997 5855
1998 5783
1999 5779
2000 6276
2001 6191
2002 6183
2003 6327
2004 6440
2005 6367
2006 6544
2007 6521
2008 6458
2009 6670
2010 6913
2011 7213
2012 7376
2013 7741
2014 7611
2015 7653
2016 7176
2017 7382
2018 7297
2019 7590
2020 8461
2021 8467
2022 9213
2023 7773
2024 8343
2025 8738
2026 5436
2027 2

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328,088 results

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Page 1
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Wang P, Doxtader KA, Nam Y. Wang P, et al. Mol Cell. 2016 Jul 21;63(2):306-317. doi: 10.1016/j.molcel.2016.05.041. Epub 2016 Jun 30. Mol Cell. 2016. PMID: 27373337 Free PMC article.
How Mettl3 and Mettl14 cooperate to catalyze methylation of adenosines has remained elusive. We present crystal structures of the complex of Mettl3/Mettl14 methyltransferase domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH …
How Mettl3 and Mettl14 cooperate to catalyze methylation of adenosines has remained elusive. We present crystal structures of the com …
Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism.
Ogawa A, Watanabe S, Ozerova I, Tsai AY, Kuchitsu Y, Chong HB, Kawakami T, Fuse J, Han W, Kudo R, Naito T, Sato K, Nakazawa T, Saheki Y, Hirayama A, Stadler PF, Arisawa M, Araki K, Bar-Peled L, Taguchi T, Sawa S, Inaba K, Wei FY. Ogawa A, et al. Cell. 2025 Oct 30;188(22):6151-6169.e24. doi: 10.1016/j.cell.2025.07.041. Epub 2025 Aug 20. Cell. 2025. PMID: 40840445 Free article.
After phosphorylation by adenosine kinase (ADK), they undergo deamination by adenosine deaminase-like (ADAL). In Adal knockout mice, N(6)-modified adenosine monophosphates (AMPs) accumulate and allosterically inhibit AMP-activated protein kinase (AMPK), dysre …
After phosphorylation by adenosine kinase (ADK), they undergo deamination by adenosine deaminase-like (ADAL). In Adal knockout …
Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo.
Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, Wei W. Yi Z, et al. Nat Biotechnol. 2022 Jun;40(6):946-955. doi: 10.1038/s41587-021-01180-3. Epub 2022 Feb 10. Nat Biotechnol. 2022. PMID: 35145313
To lower off-target editing we deleted pairings of uridines with off-target adenosines, which almost completely eliminated bystander off-target adenosine editing. Engineered circ-arRNAs enhanced the efficiency and fidelity of editing endogenous CTNNB1 and mutant TP5 …
To lower off-target editing we deleted pairings of uridines with off-target adenosines, which almost completely eliminated bystander …
Adenosine-associated delivery systems.
Kazemzadeh-Narbat M, Annabi N, Tamayol A, Oklu R, Ghanem A, Khademhosseini A. Kazemzadeh-Narbat M, et al. J Drug Target. 2015;23(7-8):580-96. doi: 10.3109/1061186X.2015.1058803. J Drug Target. 2015. PMID: 26453156 Free PMC article. Review.
Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat (arrhythmias), regulation of central nervous system (CNS) activity and inhibiting seizural episodes can be carried out using adenosine …
Adenosine is a naturally occurring purine nucleoside in every cell. Many critical treatments such as modulating irregular heartbeat ( …
18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis.
Liberman N, Rothi MH, Gerashchenko MV, Zorbas C, Boulias K, MacWhinnie FG, Ying AK, Flood Taylor A, Al Haddad J, Shibuya H, Roach L, Dong A, Dellacona S, Lafontaine DLJ, Gladyshev VN, Greer EL. Liberman N, et al. Mol Cell. 2023 Sep 21;83(18):3268-3282.e7. doi: 10.1016/j.molcel.2023.08.014. Epub 2023 Sep 8. Mol Cell. 2023. PMID: 37689068 Free PMC article.
This intergenerational hormesis is accompanied by a heritable increase in N6'-dimethyl adenosine (m(6,2)A) on the 18S ribosomal RNA at adenosines 1735 and 1736. We identified DIMT-1/DIMT1 as the m(6,2)A and BUD-23/BUD23 as the m(7)G methyltransferases in C. elegans …
This intergenerational hormesis is accompanied by a heritable increase in N6'-dimethyl adenosine (m(6,2)A) on the 18S ribosomal RNA a …
[Adenosine].
Tebbenjohanns J, Lüderitz B. Tebbenjohanns J, et al. Internist (Berl). 1995 Mar;36(3):296-9. Internist (Berl). 1995. PMID: 7737824 Review. German. No abstract available.
The adenosine-mediated, neuronal-glial, homeostatic sleep response.
Greene RW, Bjorness TE, Suzuki A. Greene RW, et al. Curr Opin Neurobiol. 2017 Jun;44:236-242. doi: 10.1016/j.conb.2017.05.015. Epub 2017 Jun 19. Curr Opin Neurobiol. 2017. PMID: 28633050 Free PMC article. Review.
This sleep-homeostasis related SWA results from a buildup and decay of extracellular adenosine that acts at neuronal adenosine A1 receptors to facilitate SWA and is metabolized by adenosine kinase found in glia. This local neuronal-glial circuit for homeostat …
This sleep-homeostasis related SWA results from a buildup and decay of extracellular adenosine that acts at neuronal adenosine …
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution.
Lee YS, Levdansky Y, Jung Y, Kim VN, Valkov E. Lee YS, et al. Nat Struct Mol Biol. 2024 May;31(5):826-834. doi: 10.1038/s41594-023-01187-1. Epub 2024 Feb 19. Nat Struct Mol Biol. 2024. PMID: 38374449 Free PMC article.
Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in mRNA decay and is highly regulated during gene expression. The incorporation of non-adenosines in poly(A) tails, or 'mixed tailing', has been observed in vertebrates and viruses. ...App …
Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in mRNA decay and is highly regulated during gene expre …
N6-Methyladenosines Modulate A-to-I RNA Editing.
Xiang JF, Yang Q, Liu CX, Wu M, Chen LL, Yang L. Xiang JF, et al. Mol Cell. 2018 Jan 4;69(1):126-135.e6. doi: 10.1016/j.molcel.2017.12.006. Mol Cell. 2018. PMID: 29304330 Free article.
N(6)-methyladenosine (m(6)A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I diff …
N(6)-methyladenosine (m(6)A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at ade …
[Adenosine and its role in physiology].
Novotný J. Novotný J. Cesk Fysiol. 2015;64(1):35-44. Cesk Fysiol. 2015. PMID: 26738245 Review. Slovak.
Adenosine is formed by enzymatic degradation of adenosine triphosphate and eliminated by phosphorylation to adenosine monophosphate or by deamination to inosine. ...Extracellular adenosine as a signaling molecule binds to adenosine receptors, wh …
Adenosine is formed by enzymatic degradation of adenosine triphosphate and eliminated by phosphorylation to adenosine m …
328,088 results
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